Background: Living successfully with diabetes mellitus requires the very large task of managing a serious chronic condition. The tasks associated with diabetes can be complex and demanding and most people in their life journey with diabetes report great frustration with the burden of the disease. Aim: Study of the effect of Glycemic Control on the Diabetes-Related Distress in a sample of Egyptian patients with Diabetes mellitus. Patients and methods: this a cross sectional study conducted on 350 patients with T2DM attending the outpatient clinic of endocrinology of El Agouza Police Hospital.Fasting blood glucose, Post prandial blood glucose, HbA1c, hs-CRP, Creatinine, BUN, SGPT and SGPT were assessed, BMI, Waist /Hip Ratio, also Diabetes Distress Screening Scale Questionnaire was completed by the patients.Results: There is a statistically significant positive relationship between HbA1c and Total DDS score, Emotional burden, Physician related distress, Regimen related distress, and Interpersonal distress with P-value 0.000, 0.000, 0.000, 0.032, and 0.001 respectively. Conclusion:Diabetes related Distress is associated with poor glycemic control and also inflammation.

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