Background: One of the most significant modifiable risk factors for coronary artery disease (CAD) is dyslipidemia. Acute coronary syndromes (ACS) were shown to be a key contributing factor to patients being admitted to the Coronary Care Unit (CCU) at Sohag University Hospital. Objectives: To analyze lipid profile in patients with ACS who presents at Sohag university hospital, and its clinical and complications pattern. Patiets and methods: This study involved 100 patients above 18 years old diagnosed with ACS. Patients were classified into 3 groups; ST-elevation MI (STEMI), non-ST-elevation MI (NSTEMI) and unstable angina (UA) group. All participants were subjected to history taking, clinical assessment and measuring complete lipid profile values. Results: STEMI group has higher significant total cholesterol (TC), low-density lipoprotein cholesterol LDL-C (P < 0.001), Triglycerides (TG) (P =0.022), TC/HDL (P =0.027 ) and TG/HDL levels (P = 0.001) and lower significant high-density lipoprotein cholesterol (HDL-C) (p=0.006) than other groups. There was a significant correlation between age groups and TC (P<0.001), LDL-c (P=0.009), very low-density lipoprotein cholesterol (VLDL-c) (P=0.016), HDL (P=0.001), Triglycerides (P=0.008), TC/HDL (P<0.001) and TG/HDL (P=0.040). Furthermore, there was no significant correlation between gender and TC, LDL-c, VLDL, HDL, TG, TC/HDL and TG/HDL (P>0.05). Conclusion:Patients with ACS have a significant prevalence of dyslipidemia as a risk factor. These individuals are more likely to have low HDL than high LDL values; nevertheless, they are more likely to have high TG values than low HDL values.

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Background: Gender differences in risk factors and clinical presentations of patients with acute coronary syndrome (ACS) have been reported in different parts of the world with contradicting results. AIM: This study aimed to evaluate the gender differences in baseline characteristics &to investigate the presence of gender bias in patients admitted with ACS at Sohag University Hospitals. Patients& Methods: All the patients underwent the followings: (1)A detailed history was taken including traditional risk factors (2) Full clinical examination (3) Laboratory investigations: Fasting sugar, lipid profile, cardiac enzymes, blood count. (4) Electrocardiograph &echocardiography. Results: The current study included equal numbers of both genders with 100 females & 100 males. Females were significantly older than males (58.22±5.99 Vs 53.48±4.16), p<0.0001), more obese (25.64±3.40 Vs 24.26±2.34, P = 0.001), less smokers (8% vs. 44%, respectively, P < 0.0001), more diabetic and hypertensives (65% Vs 37% , p <0.0001 and (65% Vs 42% , p =.001 respectively)but non significant differences detected regarding dyslipidemia or family history of premature CAD. Atypical symptoms were more pronounced in females (42% vs. 28%, P < 0.003), unstable angina was more common in females (72% vs. 50%, P < 0.001), while STEMI was more pronounced in males (41% vs. 19%, P < 0.001). Furthermore, hemoglobin level was significantly lower in females and higher levels of HDL were observed. Females also had a better LV systolic function. Conclusion: gender differences in some risk factors & clinical presentation was documented in ACS patients admitted to Sohag university hospitals.