Background: One of the most significant modifiable risk factors for coronary artery disease (CAD) is dyslipidemia. Acute coronary syndromes (ACS) were shown to be a key contributing factor to patients being admitted to the Coronary Care Unit (CCU) at Sohag University Hospital. Objectives: To analyze lipid profile in patients with ACS who presents at Sohag university hospital, and its clinical and complications pattern. Patiets and methods: This study involved 100 patients above 18 years old diagnosed with ACS. Patients were classified into 3 groups; ST-elevation MI (STEMI), non-ST-elevation MI (NSTEMI) and unstable angina (UA) group. All participants were subjected to history taking, clinical assessment and measuring complete lipid profile values. Results: STEMI group has higher significant total cholesterol (TC), low-density lipoprotein cholesterol LDL-C (P < 0.001), Triglycerides (TG) (P =0.022), TC/HDL (P =0.027 ) and TG/HDL levels (P = 0.001) and lower significant high-density lipoprotein cholesterol (HDL-C) (p=0.006) than other groups. There was a significant correlation between age groups and TC (P<0.001), LDL-c (P=0.009), very low-density lipoprotein cholesterol (VLDL-c) (P=0.016), HDL (P=0.001), Triglycerides (P=0.008), TC/HDL (P<0.001) and TG/HDL (P=0.040). Furthermore, there was no significant correlation between gender and TC, LDL-c, VLDL, HDL, TG, TC/HDL and TG/HDL (P>0.05). Conclusion:Patients with ACS have a significant prevalence of dyslipidemia as a risk factor. These individuals are more likely to have low HDL than high LDL values; nevertheless, they are more likely to have high TG values than low HDL values.