A new series of quinoline chalcones have been prepared from condensations of 2-chloro-3-formyl quinoline (1) with 4-(benzothio) acetophenone(2) and 4-(benzyl sulfonyl) acetophenone(3). The reaction of chalcones(4,5) with bromine gives dibromide(6,7). New pyrazoline derivatives were synthesized by condensation of chalcones (4 or 5) with hydrazine hydrate to give (8,9) and with hydrazine hydrate in glacial acetic acid(gla) to give (10,11) and with phenyl hydrazine to give (12,13). The prepared chalcones (4,5) and dibromide(6,7) and pyrazoline derivative (8-13)have been screened for antibacterial activities against two gram positive staphylococcus aureus and staphylococcus epidermidis and two gram negative Escherichia coli and Proteus vulgaris. The synthesized compounds are proven by IR & NMR spectral and physical method.

This article deals with synthesis, Identification and biological activity screening of variety 1,3-thiazolidin-4-ones entitled 3,3’-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis[(5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one)] 6a-d and 3,3’-[benzene-1,3-diylbis(5-mercapto-4H-1,2,4-triazole-3,4-diyl)]bis[5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one], 7a-d. On cyclocondensation reaction of newly Schiff bases and thiolactic acid, some new derivatives of 1,3-thiazolidin-4-ones have been obtained in presence of anhydrous zinc chloride. The elemental analysis, proton NMR spectra of were outlined for structures confirmation. An agreement for the proposed structures of synthesized compounds were approved based on the elemental analysis, IR and 1H NMR spectra. Antimicrobial activity of the newly thiazolidinones have been evaluated with powerful results.