ABSTRAK Bahan alam digunakan manusia sebagai obat untuk menyembuhkan, mencegah penyakit tertentu dan menjaga kondisi badan agar tetap sehat. Bahan alam yang digunakan dikenal dengan istilah obat herbal. Mentimun (Cucumis sativus L) dan Nanas (Ananas cosmosus (L) Merr) merupakan sebagian dari bahan alam yang dapat digunakan sebagai alternatif pengobatan. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa kimia pada ekstrak etanol mentimun dan ekstrak etanol nanas yaitu senyawa saponin, steroid, terpenoid, tanin dan secara kualitatif. Ekstrak etanol mentimun dan ekstrak etanol nanas didapatkan dengan metode maserasi. Hasil identifikasi senyawa kimia menunjukan ekstrak etanol mentimun mengandung senyawa kimia terpenoid, saponin dan fenolik. Ekstrak etanol nanas mengandung terpenoid dan fenolik. Kata kunci: Identifikasi senyawa kimia, Mentimun (Cucumis sativus L), Nanas (Ananas cosmosus (L) Merr) ABSTRACT Natural materials has used by humans as a medicine to cure, prevent certain diseases and maintain body condition in order to stay healthy. Natural materials are used is known as herbal medicine. Cucumber (Cucumis sativus L) and Pineapple (Ananas cosmosus (L) Merr) is part of the natural materials that can be used as an alternative treatment. This study aims to identified the chemical compounds in extracts of cucumber ethanol and ethanol extract of pineapple there are saponins, steroids, terpenoids, tannins and qualitatively. The ethanol extract of cucumber and pineapple ethanol extracts obtained by maceration method. The results of the identification of chemical compounds showed the ethanol extract of cucumber contains chemical compounds terpenoids, saponins and phenolic. The ethanol extract of pineapple contains terpenoids and phenolic. Keywords: Identification of chemical compounds, cucumber (Cucumis sativus L), pineapple (Ananas comosus (L) Merr)

The use of ethanol as a solvent for secondary metabolite compounds is very widespread. Ethanol can dissolve flavonoid compounds and phenolic compounds from plants. To be able to utilize ethanol as a solvent is dependent on some factors of concentration, temperature, time, and selection of extraction methods. This study uses the method by searching scientific articles from the MDPI website database. The Ultrasound-Assisted Extraction (UAE) method is very suitable for the optimization of ethanol as a solvent. The optimal use of ethanol is in the concentration range of 50-80%, temperature conditions in the range of 40-70�C, and the extraction time is in the range of 30 minutes - 24 hours.

Indonesia memiliki kekayaan alam yang berlimpah, yang dimanfaatkan sebagai obat tradisional untuk masyarakat. Daun Gelinggang (Senna alata L) memiliki aktivitas antijamur berdasarkan senyawa metabolit sekunder berupa flavonoid, saponin, tanin steroid, alkaloid yang diharapkan dapat menjadi alternativ lain dalam pengobatan antijamur. Tujuan penelitian ini adalah untuk menganalisis kadar flavonoid total dari fraksi Daun Gelinggang dengan metode spektrofotometri UV-Vis. Penelitian ini menggunakan Analisis kualitatif mengidentifikasi senyawa flavonoid sedangkan analisis kuantitatif untuk menentukan kadar flavonoid menggunakan spektrofotometri uv-vis yang akan diperoleh nilai dari absorbansi dimasukkan ke dalam persamaan regresi linear yaitu y = bx + a yang diperoleh dari kurva kalibrasi perbandingan dan hasil dinyatakan dalam satuan mg/gram dan persen. Hasil penelitian dari identifikasi uji warna shinoda pada ekstrak daun gelinggang positif mengandung flavonoid yang berwarna hijau lumut dan penetapan kadar flavonoid total dari daun gelinggang sebesar 2,563%. Dari penelitian ini dapat disimpulkan bahwa fraksi n-heksana memiliki kadar flavonoid sebesar 2,563%. Determination of Total Flavonoid Content of the n-Hexane Fraction of Gelinggang Leaf Extract by UV-Vis Spectrophotometric Method Abstract: Indonesia has abundant natural resources, which are used as traditional medicine for the community. Gelinggang leaf (Senna alata L) have antifungal activity based on secondary metabolites in the form of flavonoids, saponins, steroid tannins, and alkaloids which are expected to be other alternatives in antifungal treatment. The research objective is to analyze the total flavonoid content of the Gelinggang Leaf fraction using the UV-Vis spectrophotometry method. This study used qualitative analysis to identify flavonoid compounds and quantitative analysis to determine flavonoid levels using UV-Vis spectrophotometry. The absorbance value obtained is entered into the linear regression equation, namely y = bx + a from the comparison calibration curve and the results are expressed in units of mg/gram and percent. The results of the identification of the Shinoda color test on Gelinggang leaf extract were positive for moss-green flavonoids and the determination of the total flavonoid content of Gelinggang leaf was 2.563%. From this study, it can be concluded that the n-hexane fraction has a flavonoid content of 2.563%. Keywords: Gelinggang Leaf, N-hexane Fraction, Total Flavonoid Content, UV-VIS Spectrophotometry Method.

Hypertension is still the most common disease in the world. South Kalimantan Province in 2018 became the province with the highest number of hypertension sufferers in Indonesia. Hypertensive patients will undergo hypertension therapy for the rest of their lives so that blood pressure can still be well controlled. Lifelong therapy can reduce patient compliance in taking hypertension drugs; this can result in failed therapeutic goals and lead to the emergence of other diseases such as myocardial infarction and others. The purpose of this study was to analyze sociodemographic factors and clinical factors that may be related to patient compliance in taking hypertension drugs in Banjar Regency. The results showed that the majority of respondents had low compliance in consuming hypertension drugs. The analysis showed that sociodemographic factors such as gender, age, occupation, and place of getting the drug and clinical factors in the form of drugs used and blood pressure control did not show a significant relationship. The education factor shows a p-value < 0.05, which indicates the education factor has a significant relationship.

Kulit buah Cempedak yang digoreng (Manday) merupakan salah satu makanan yang umum dikonsumsi masyarakat di Kalimantan Selatan. Berdasarkan pengalaman dari beberapa masyarakat, keluhan yang sering terjadi adalah perut terasa perih dan kepala pusing. Evaluasi sifat toksik dari bagian tumbuhan yang dikonsumsi oleh masyarakat sangat penting untuk dilakukan dengan mempertimbangkan perlindungan kesehatan masyarakat karena paparan senyawa kimia dari bagian tumbuhan yang dapat menyebabkan efek yang tidak diinginkan pada masyarakat. Penelitian ini bertujuan untuk mengidentifikasi senyawa kimia dan efek toksisitas akut dari ekstrak etanol kulit buah cempedak. Kulit buah cempedak dikeringkan dengan menggunakan oven. Ekstraksi kulit buah cempedak menggunakan cara maserasi dengan cairan penyari etanol. Tikus uji diberi larutan kontrol Na CMC dan ekstrak dengan dosis 300 mg/kgBB, 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB. Hasil identifikasi senyawa kimia didapatkan positif mengandung triterpenoid, flavonoid, tanin, dan senyawa fenolik. Tikus uji yang menerima ekstrak dengan dosis 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB terjadi perubahan pada tikus uji berdasarkan pengamatan fisik yaitu mengalami peningkatan detak jantung atau takikardi, pernapasan cepat, tremor, dan agresif. Kata kunci: Kulit buah cempedak, senyawa kimia, toksisitas akut Rind of Cempedak fruit (Manday) is one of the foods commonly consumed by people in South Kalimantan. Based on the experience of several communities, complaints that often occur are sore stomach and headache. Evaluation of the toxic properties of plant parts consumed by the community is very important to be done by considering public health protection due to exposure to chemical compounds from parts of plants that can cause undesirable effects on the community. This study aims to identify chemical compounds and acute toxicity effects of ethanol extract rind of cempedak fruit. Rind of Cempedak fruit has dried using an oven. Extraction of cempedak fruit skin using maceration method with ethanol. Test rats were given Na CMC as a control and extract with dose 300 mg / kgBB, 1000 mg / kgBB, 2000 mg / kgBB, and 5000 mg / kgBB. The results of the identification of chemical compounds were obtained positively containing triterpenoids, flavonoids, tannins, and phenolic compounds. The test rats that received extracts at a dose of 1000 mg / kgBW, 2000 mg / kgBB, and 5000 mg / kgBW were changed in the test rats based on physical observations that experienced an increase in heart rate or tachycardia, rapid breathing, tremor, and aggressive. Keywords: acute toxicity, chemistry compounds, rind of cempedak fruit