BackgroundRoughly half of all extremely preterm infants will be diagnosed with bronchopulmonary dysplasia (BPD), and a third will be discharged on home oxygen therapy (HOT). To date, there have been no studies that have examined the relationship between respiratory medication utilization in infants with BPD on HOT.MethodsThe recorded home oximetry trial was a multicenter, randomized trial comparing two home oxygen management strategies in premature infants. Infants were enrolled at first outpatient pulmonary or neonatal intensive care unit (NICU) follow‐up visit with a pulmonary component. Respiratory medication prescriptions and dosage were collected from time of enrollment through 6 months after HOT discontinuation. Patients were seen monthly while on HOT and at 1, 3, and 6 months after successful discontinuation.ResultsDuring protocol visits, 174 (89%) infants had respiratory medications documented. Respiratory medication use was higher at initial follow‐up visit compared with NICU discharge and decreased at the final 6‐month follow‐up visit. Infants who received inhaled steroids (IS) before weaning had mean HOT duration of 138 days (range: 24‐562 days); infants who received IS after weaning had shorter mean HOT duration (55 days, range: 21‐264). In time‐to‐event analysis the no IS group and the postwean group differed significantly (χ21 = 8.1; P = .004). NICU clinics gave a total of 35 prescriptions to 43 patients, an average of 0.8 per patient, while the pulmonary clinics gave 837 prescriptions to 153 patients, or 5.5 per patient (P < .0001).ConclusionRespiratory prescribing patterns for infants on HOT are highly variable. Utilization of IS was not associated with shorter duration of HOT.