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In this study, a novel molecularly imprinted polymer (MIP) based on methacrylic acid (MAA) monomer was synthesized to control release of trinitroglycerin (TNG) as a vasodilator drug for adjusting the cardiac conditions. For this purpose, TNG nanospheres based on poly(methacrylic acid) (PMAA) were prepared by using the precipitation polymerization process. The synthesized TNG nanospheres-based MIP samples were characterized by means of Fourier transform infrared spectroscopy and field-emission scanning electron microscopy in order to investigate their provided active functional groups within the cavities as well as morphology, respectively. The results showed that the appropriate non-covalent bindings between the TNG (template) and PMAA provided within the MIP samples with imprinting factor of 1.98 were achieved by optimizing the amounts of trimethylolpropane trimethacrylate (TRIM) as a cross-linker and MAA as a functional monomer. On the basis of these obtained conditions, the polymeric nanospheres containing TNG were formed in shape of spherical particles with an average diameter sizing about 40 nm. These remarkable results were obtained by the use of 1:10 molar ratio of TRIM/TNG and 1:6 molar ratio of MAA/TNG. Moreover, in-vitro release of the TNG from the MIP samples to phosphate buffer solution (pH = 7.4) indicated that the MIP samples had a moderate and gradual release compared with the non-imprinted polymer samples. These outcomes conducted us to consider the samples as carriers for adjusting potentially cardiac conditions.

Schematic design of a new method for fabrication of biocompatible pH sensitive halloysite nanocomposites for controlled release of phenytoin sodium.