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In this paper, we investigated effects of deep brain stimulation (DBS) on Parkinson's disease (PD) when different target sites in the basal ganglia are stimulated. The targets which are investigated are subthalamic nucleus (STN), globus pallidus interna (GPi), and globus pallidus externa (GPe). For this purpose we used a computational model of the basal ganglia-thalamocortical system (BGTCS) with parameters calculated for mean field. This model is able to reproduce both the normal and Parkinsonian activities of basal ganglia, thalamus and cortex in a unified structure. In the present study, we used a mean-field model of the BGTCS, allowing a more complete framework to simulate DBS and to interpret its effects in the BGTCS. Our results suggest that DBS in the STN and GPe could restore the thalamus relay activity, while DBS in the GPi could inhibit it. Our results are compatible with the experimental and the clinical outcomes about the effects of DBS of different targets.

In this paper we investigated by a computational model of the basal ganglia-thalamocortical system (BGTCS) differences between the motor cortex stimulation (MCS) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) of the basal ganglia (BG) in Parkinson's disease (PD). To this end, a mean-field model of the BGTCS is used. This model is able to reproduce both the normal and parkinsonian activities of the BG, thalamus and motor cortex in a unified structure. Using this model, we simulate DBS and MCS, and compared the effect of location of stimulation on mean firing rates of the BGTCS. Our results suggest that DBS of the STN and MCS could restore thalamus relay activity, but DBS effects on PD are stronger than MCS. Consequently, stimulation of cortex seems to mimic the stimulation of STN in a relatively less effective manner. Our results are compatible with the experimental and the clinical outcomes on the effects of DBS and MCS.