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Campomanesia xanthocarpa, a plant belonging to the Myrtaceae family, is popularly known as gabiroba. Leaves of gabiroba has been popularly used to treat various diseases, including inflammatory, renal, and digestive, among others. Additionally, studies have shown an effect to reduce blood cholesterol levels. The aim of this study was to evaluate the antihyperglycemic and hypolipidemic effects of Campomanesia xanthocarpa seed extract in hyperglycemic rats. The results showed that 400 mg/kg of seed extract was able to decrease blood glucose levels and to increase the muscular and hepatic glycogen content as well as to inhibit the sucrase and maltase activity. At doses of 200 mg/kg and 800 mg/kg, the activity of these enzymes was also reduced. In the lipid profile 400 mg/kg produced a decrease in total and LDL cholesterol serum levels; and with 200 mg/kg there was an increase in HDL cholesterol levels. The extract did not present hepatic and renal toxic effects at the different doses tested. The results suggest that the treatment with Campomanesia xanthocarpa seeds extract is useful in reducing glycemia, total cholesterol and LDL levels with potential adjuvant therapeutic in the treatment of diabetes and hypercholesterolemia, however, additional pharmacological and toxicological studies are still required.

RESUMO:A levedura Candida spp., pertencente à microbiota normal, pode causar graves infecções, principalmente em pacientes no ambiente hospitalar. Os variados graus de patogenicidade e sensibilidade a antifúngicos apresentados pelas diversas espécies, combinados ao aumento da frequência de infecções por Candida spp. e às altas taxas de morbimortalidade, apontam a importância da identificação das espécies, assim como a realização de testes de suscetibilidade para o sucesso do tratamento de candidíases. Neste estudo foram identificadas espécies de Candida em isolados clínicos de pacientes atendidos em um hospital da região oeste de Santa Catarina, Brasil, utilizando o método CHROMagar Candida, bem como avaliados seus respectivos perfis de suscetibilidade a antifúngicos usados no âmbito hospitalar utilizando o método de disco-difusão em ágar. Das 43 amostras analisadas, a maior prevalência da candidíase foi encontrada em pacientes com idade entre 51 e 70 anos e do gênero masculino. A maioria do isolados foi obtida de amostras de urina (n=25) e da Unidade de Terapia Intensiva (n=22). As espécies mais frequentes foram C. albicans (n=24) e C. glabrata (n=13). A maioria dos isolados foi sensível à anfotericina B (86,05%) e a minoria (13,95%) sensível ao fluconazol. O setor de UTI, as amostras de urina e as culturas identificadas como C. albicans apresentaram vários isolados resistentes a todos os antifúngicos testados. O elevado número de isolados resistentes aos antifúngicos azólicos, provenientes principalmente de pacientes de UTI, indicam a importância do antifungigrama para a escolha do antifúngico e da dose mais adequados no tratamento de candidíases em pacientes críticos. PALAVRAS-CHAVE:Candidíase; Infecção Hospitalar; Testes de Sensibilidade Microbiana. Candida spp. IN CLINICAL ISOLATES AND SUSCEPTIBILIT Y TO ANTIFUNGALS AGENTS IN HOSPITALS ABSTRACT:The yeast Candida spp. belongs to the normal microbiota and may cause severe infections, mainly in hospitalized patients. The various degrees of pathogenicity and sensitiveness to antifungal agents by the several species, plus increase in the frequency of infections by Candida spp. and high morbo-mortality rates, underscore the importance of identifying the species and undertaking susceptibility tests for the treatment of candidiasis. Candida species were identified by the CHROMagar Candida method, in clinical isolates from patients who attended a hospital in the western region of the state of Santa Catarina, Brazil. Susceptibility profiles to antifungal agents used in hospital were evaluated by the agar disc-diffusion method. The greatest prevalence of candidiasis in 43 samples occurred in male patients within the 51-70 age brackets. Most isolates were obtained

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