Indonesia is the largest Muslim population country in the world, so the market demand for halal products is enormous. However, in fact, there are not many business actors who submit and have halal certificates, especially in small and medium enterprises. This problem can be due to lack of information and sufficient understanding to apply for a halal certificate. The aim of the research is to give technical guidance for preparing halal certification process. The manual method is used to provide training on the halal guarantee system for the preparation of the halal assurance system (HAS). The workshop began with a pre-test and then the presentation of halal assurance system material, the guidance on how to prepare and discussion. All the activities were done by online (WhatsApp group and zoom meeting). The training ended with the post-test to assess the improvement of knowledge of the. To analyze the difference, we used a paired T-test statistical method. The result of this research shows an increasing understanding of participants (p<0,05) through the comparison between before and after training. These activities conclude that the practice of technical guidance for facing halal certification is beneficial for small and medium enterprises in improving knowledge and capability of the halal certification process.

The aim this study is to obtain an effective and efficient of method for assay of acyclovir cream determination. Chromatographic separation on a reverse phase a YMC - Triart C18 column (4.6 x 150 mm, 5 μm), the mobile phase consisted of water and acetonitrile (95: 5 v/v) at a flow rate 1.2 mL/min with UV-Vis detection at 252 nm, volume injected was 20 μL, with UV detection at 252.0 nm. The retention time of acyclovir was ± 3.5 min. Validation studies were achieved by using the limit of detection (LOD) and limit of quantification (LOQ), precision, accuracy, selectivity parameter. The LOD and LOQ values were 0.27 µg/mL and 0.83 µg/mL. The average standard deviation (RSD) value of precision is 0.35% and accuracy is 0.34%. Robustness shows that the method is resistant to variation in the mobile phase, the Acyclovir cream analysis method meets the ICH 1994 requirements, so it can be applied to the assay of Acyclovir determination in Cream dosage forms.

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