Background COVID-19 infection can show various manifestation, including neurologic manifestations, such as anosmia, ageusia, or dysgeusia, and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephalopathy, and many more. Aim To briefly review neurologic manifestation in COVID-19 infection in the Asia region (South East Asia and the Western Pacific Region). Material and methods This review uses the PRISMA statement and checklist. The source for reviewed article was performed in PubMed that were published between December 2019 to September 2020 with the latest 1 year of publication. Study titles were first screened, then reviewed by title and abstract and then the last review, we tested full text and applied eligibility criteria. Results We found a total of 9 retrieved articles from the electronic database. Among these 9 articles, 5 of them are case report, 1 case series, 1 prospective multi-center cohort study, 1 retrospective multi-center study, and 1 retrospective observational study. All articles reported confirmed COVID-19, confirmation by positive swab test using the real-time RT-PCR method, with neurologic manifestations, disorder, or syndrome on presentation or found during hospital stay. In case of neurologic disorder or syndrome, the studies reported encephalitis and ADEM, acute cerebrovascular disease, acute symptomatic seizure, and Guillain-Barré syndrome with acute cerebrovascular disease as the most common neurologic disorder associated with COVID-19 infection, followed by encephalitis. Conclusion COVID-19 also affects the brain, which may result in a global or focal neurologic manifestation. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome. Guillain-Barre syndrome, encephalopathy, and many more. This review will briefly review neurologic manifestation in COVID-19 infection in the Asian region (South East Asia and the Western Pacific Region. A total of 9 retrieved articles from the electronic database reported confirmed COVID-19, confirmation by RT-PCR method, with neurologic manifestation, disorder, or syndrome on presentation or found during hospital stay. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome.

Hematoma epidural spinal spontan atau spontaneous spinal epidural hematoma (SSEH) adalah akumulasi darah di ruang epidural tulang belakang yang menekan medula spinalis dan menimbulkan defisit neurologis. SSEH dapat terjadi di segmen mana saja dari medula spinalis dan penyebab pasti serta sumber perdarahan yang pasti hingga saat ini masih belum diketahui. Diagnosis SSEH dapat ditegakkan dengan pemeriksaan penunjang MRI. Tatalaksana pilihan untuk kasus SSEH adalah laminektomi dekompresi dan evakuasi hematoma. Pada kasus ini, pasien datang dengan keluhan paraparesis inferior tipe UMN dan gangguan sensibilitas yang akut tanpa riwayat trauma dan faktor risiko yang berhubungan dengan SSEH. Pasien menjalani laminektomi dan menunjukkan perbaikan klinis yang signifikan. Spontaneous spinal epidural hematoma (SSEH) is an accumulation of blood in epidural space of the spine compressing spinal cord and causing neurological deficits. SSEH can occur in any segments of the spinal cord and the definite etiology and source of bleeding is still unknown until now. MRI can be used to support SSEH diagnosis. Treatment of choice for SSEH cases is decompression laminectomy and hematoma evacuation. In this case, the patient came with acute paraparesis upper motor neuron type and sensibility disturbances, without history of trauma and any risk factors associated with SSEH. The patient underwent laminectomy and showed significant clinical improvement.

Latar Belakang: Hemodialisis adalah suatu prosedur yang digunakan untuk membantu ginjal melakukan tugasnya mengeluarkan zat-zat dari dalam tubuh. Salah satu dampak dari menjalani terapi hemodialisis adalah penurunan perfusi serebral dan penurunan kecepatan aliran darah otak sehingga dapat menyebabkan penurunan fungsi kognitif. Gangguan kognitif dan demensia telah banyak dilaporkan terjadi pada pasien penyakit ginjal kronik terutama yang menjalani terapi hemodialisis. Tujuan: Tujuan penelitian ini adalah untuk mengetahui angka profil  gangguan kognitif pada pasien hemodialisis di RSUD Wangaya. Metode: Penelitian ini merupakan penelitian deskriptif dengan metode potong lintang dan dilakukan pada bulan Agustus sampai dengan September 2019. Populasi target dan sampel pada penelitian ini adalah semua pasien hemodialisis di RSUD Wangaya yang memenuhi kriteria inklusi. Penelitian ini dilakukan dengan wawancara dan kuesioner Montreal Cognitive Assessment versi Indonesia (MoCA-Ina). Data yang diperoleh ditabulasi dengan menggunakan program SPSS. Hasil: Hasil penelitian ini didapatkan prevalensi gangguan kognitif pada pasien yang menjalani terapi hemodialisis sebesar 90% dengan domain kognitif yang paling sering terganggu adalah domain  delayed memory (27,5%). Sebanyak 66% yang mengalami gangguan kognitif adalah yang telah menjalani terapi hemodialisis selama lebih dari 2 tahun.