Background: Ventricular Septal Defect is a Congenital Heart Defect characterized by an opening in interventricular septum or more that happen because of intraventricular septum’s failure to fuse during fetal development. Ventricular Septal Defect itself is the most prevalent type of CHD found on pediatric patient and decreased their quality of life thus corrective treatment become important to ensure child healthy growth. Transcatheter procedure is expected as one of the alternative for corrective treatment which is better and safer compared to surgical closure of VSD corrective treatment. Objectives: This research aimed to observe the comparison of VSD closure between transcatheter compared to surgical closure. Methods: This research is a systematic review and meta-analysis compliant with PRISMA guidelines and analyzed using Review Manager 5.3. Discussion: This research identifies 1.991 journals however, only 10 journals fulfilled the inclusion criteria. The review founded that there is no significant difference between either transcatheter or surgical closure outcome (RR = 0,99) however the analysis founded that transcatheter method are much safer in term of complication event (RR =0,54), residual shunt event (RR = 0,56), and blood transfusion (RR=0,03) while also provide a much cheaper cost with faster procedure time, and hospitalization. Conclusion: The results of data analysis found that transcatheter procedure is safer, cheaper, and have a much faster speed in term of operation duration and hospital stay compared to surgical closure of VSD. Transcatheter procedure is recommended as treatment choice for corrective treatment of patient diagnosed with VSD. Keywords: Ventricular Septal Defect, transcatheter, surgical closure, child Latar Belakang: Ventricular Septal Defect adalah Penyakit Jantung Bawaan yang ditandai dengan adanya satu lubang pada septum interventrikular atau lebih yang terjadi akibat kegagalan fusi septum intraventrikular saat perkembangan janin. VSD sendiri adalah jenis PJB yang paling sering timbul pada anak dan mengakibatkan penurunan kualitas hidup anak sehingga terapi korektif menjadi penting agar anak dapat tumbuh dengan baik. Prosedur transkateter diharapkan menjadi salah satu alternatif terapi korektif yang lebih baik dibandingan dengan pembedahan dalam pengobatan korektif VSD. Tujuan: Tujuan dari penelitian ini adalah untuk melihat perbandingan penutupan VSD secara transkateter dibandingkan dengan pembedahan. Metode: Penelitian ini merupakan telaah sistematik dan meta analisis yang patuh pada kaidah pedoman PRISMA lalu dianalisis menggunakan Review Manager 5.3. Pembahasan: Penelitian ini menemukan 1.991 jurnal namun hanya 10 jurnal yang memenuhi kriteria inklusi. Telaah tersebut menemukan bahwa tidak ada perbedaan signifikan antara luaran prosedur transkateter atau pembedahan (RR = 0,99) namun analisis yang dilakukan menemukan bahwa transkateter lebih aman dalam segi kejadian komplikasi (R = 0,54), kejadian pirau residual (RR = 0,56), dan transfusi darah (RR = 0,03) dan lebih murah dalam hal biaya serta lebih cepat baik prosedur maupun lama rawat inap. Kesimpulan: Hasil analisis ini menemukan bahwa prosedur transkateter lebih aman, murah, dan lebih cepat dalam hal prosedur serta lama rawat inap dibandingkan pembedahan. Prosedur transkateter direkomendasikan sebagai pilihan prosedur untuk pengobatan korektif VSD. Kata Kunci: Ventricular Septal Defect, transkateter, pembedahan, anak
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