The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated coronavirus disease (COVID-19) has gripped the entire international community and has caused widespread public health concerns. Despite global efforts to control the disease transmission, the outbreak is still on a rise because of fast spreading of this infection by the community. Once in the human body, SARS-CoV-2 is abundantly present in nasopharyngeal and salivary secretions of affected patients, as it is predominantly transmitted through respiratory droplets and direct contact. Therefore, dental professionals may easily encounter a patient infected with SARS-CoV-2, and need to work with tremendous caution, preventing spreading of infection. Thus, the aim of this article was to provide a brief overview of epidemiology, symptoms, and routes of transmission of this novel infection. In addition, we present specific recommendations of the Polish Dental Association for dental practice for screening of patients, infection control strategies, and patient management protocol.

In developing and developed countries, an increasing elderly population is observed. This affects the growing percentage of people struggling with neurodegenerative diseases, including Alzheimer’s disease. Nevertheless, the pathomechanism of this disease is still unknown. This contributes to problems with early diagnosis of the disease as well as with treatment. One of the most popular hypotheses of Alzheimer’s disease is related to the pathological deposition of amyloid-β (Aβ) in the brain of ill people. In this paper, we discuss issues related to Aβ and its relationship in the development of Alzheimer’s disease. The structure of Aβ and its interaction with the cell membrane are discussed. Not only do the extracellular plaques affect nerve cells, but other forms of this peptide as well.

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The treatment of patients with ectodermal dysplasia in pre-school age is a troublesome process and requires a unique approach towards patient’s needs. Ectodermal dysplasia typically affects skin, hair, nail, skin glands and teeth. The characteristics of the condition include rare and thin hair on the head, sweating disorders and tooth agenesis (oligodontia or hipodontia). The treatment of juvenile patients is depending on the number of teeth and their condition. It’s begin with the multi-professional consultation, which leads to settling a combined restorative, surgical, orthodontic and prosthetic treatment. On the account of accruing malformations appearing in the patient’s appearance, the undertaking of fast interdisciplinary treatment - including the prosthetic treatment - can have key prominence not only in improving patient’s health condition, reinforcing the correct development and correction in the stomatognathic system but also in gaining acceptance in a peer group. Dissertation depicts the case of a prosthetic treatment process of a three-year-old boy with ectodermal displasia and showing contact allergy to nickel. Presented difficulties in performing medical procedures and effect of the treatment obtained with dentures.

The sirtuins (SIRTs) are a family of enzymes from the group of NAD+-dependent deacetylases. Through the reaction of splitting the acetyl group of various transcription factors and histones they regulate many processes in the organism. The activity of sirtuins is linked to metabolic control, oxidative stress, inflammation and apoptosis, and they also affect the course of viral infections. For this reason, they may participate in the pathogenesis and development of many diseases, but little is known about their role in the course of human immunodeficiency virus (HIV) infection, which is the subject of this review. In the course of HIV infection, comorbidities such as: neurodegenerative disorders, obesity, insulin resistance and diabetes, lipid disorders and cardiovascular diseases, renal and bone diseases developed more frequently and faster compared to the general population. The role of sirtuins in the development of accompanying diseases in the course of HIV infection may also be interesting. There is still a lack of detailed information on this subject. The role of sirtuins, especially SIRT1, SIRT3, SIRT6, are indicated to be of great importance in the course of HIV infection and the development of the abovementioned comorbidities.