Background: Thalassemia is the most common genetic disorder in Egypt, It is measured a fetal disease if proper chelation treatment is not established. The introduction of chelating agents able to removing extreme iron from the body has noticeably increased life expectancy time and improving the in general quality of life. the study aimed to identify the impact of an educational program about iron chelation therapy on the QoL for thalassemic children.Quasi-experimental research design was used , a convenient sample of 50 thalassemic children on chelation therapy, and their family caregiver at the pediatrics outpatient department at the Health Insurance Agency Hospital in Damietta city for 12 months from April 2015 to April 2016. The tools of data collection were an interview questionnaire for knowledge, and the pediatric QoL tool, child and parent versions. The results revealed that there were statistically significant improvement of children's knowledge with P-value = 0.001. Subsequently, statistically significant improvement of children's quality of life at follow up compared with pre-intervention phase. The study recommended repetition of this research on large sample and in various places in Egypt and make the children with Thalassemia the focus of the health care team through designing several educational program and update posters and procures that improving their knowledge and then and then release improve in the quality of life of thalassemic children.

Background: Cancer is a life threatening illness that involves emotional distress, fear of the unknown and changes in life priorities for the child and family. It is at a significant risk of depression for mothers because of the frequent stressful diagnostic tests, treatments and side effects of treatments.Aim: Assessof knowledge and reported practice of mothers having children with cancer and undergoing chemotherapy.Design: Adescriptive research design was used in the study. Data collection: a purposive sample of 50 mothers and their children with cancer at inpatient and outpatient departments at Oncology Institute in Mansoura City. Tools: An interview questionnaire formto collect data about socio-demographic characteristics for studied mothers and their children, assessment of knowledge related childhood cancer and chemotherapy sheet and reported practice of mothers related to care of their children who undergoing chemotherapy sheet. Results: revealed that, only 14% of mothers had satisfactory knowledge related childhood cancer and chemotherapy .In relation to total reported practice, only 34.0% of the studied mothers had total reported practice related to side effects management of chemotherapy.The study recommended: developing frequent educational training programs for mothers of children with cancer about care of their children who undergoing chemotherapy through updated posters, booklets and brochures and a repeat of this research on a large sample and in various places in Egypt for improving mother's knowledge and practice.