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A case-control study investigated the association between dietary fat and breast cancer in Saudi Arabian women attending a specialist hospital in Riyadh. Women with breast carcinoma [n= 499] newly diagnosed between 1996-2002, and control women [n = 498] randomly selected from patients’ attendants and relatives, completed a food frequency questionnaire. Serum levels of triglycerides and total cholesterol were measured. A significant positive association was found between risk of breast cancer and intake of fats, protein and calories. Adjusted odds ratios for the highest quartile of intake versus the lowest were 2.43 for saturated fat, 2.25 for animal protein, 2.12 for polyunsaturated fat, 1.88 for cholesterol and 2.69 for total energy from dietary intake. For serum triglycerides the adjusted odds ratio was 2.16 for the highest quartile

Background: Age and ethnicity are important factors in breast cancer (BC) disparities and outcome. However, studies examining both racial and age-related disparities are scarce. We sought to determine differences in epidemiological and clinicopathological characteristics of breast cancer between races in age-specific cohorts. Methods: Gulf Centre for Cancer Registration database and King Faisal Specialist Hospital and Research Center BC registry database for Saudi/Arab women (n=4,206) and Cancer Incidence in Five Continents Volume XI reports, and Surveillance, Epidemiology, and End Results for African-American and non-Hispanic White women with BC were used. Results: Early onset BC (age < 50 years) was more prevalent among Arab women (63%) compared with African-American women (29%) and White-American women (21%). Young Arab and African-American women had more estrogen/progesterone receptor negativity than young White-American women. The triple negative and (HER2)+/(HR)– BC subtypes were more prevalent among young Arab women compared to African-American and White women. The Arab women had the worst prognosis, especially among young women cohort. The differences persisted even after stratification to aggressive BC subtypes. The age-standardized incidence rate was significantly higher in developed countries than in Arab countries within the elderly-women cohort, but was comparable in the young women cohort. Conclusions: While young Arab and Black women had significantly higher frequency of hormonal negativity than White women, Arab women showed significantly higher prevalence of HER2+/HR- and TNBC subtypes than Black and White women. The racial/ethnic differences were more pronounced in the young women cohort. Citation Format: Dilek Colak, Olfat Al-Harazi, Hala Khalil, Maha M. Aleid, Amal N. Almadouj, Sukina Qanbar, Dahish S. Ajarim, Ibrahim H. Kaya, Ali S. Al-Zahrani. Racial and ethnic differences in breast cancer incidence, clinicopathological features and survival by age and breast cancer subtypes [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C114.