The present study tested the antifungal activity of twenty wild plants grown at the desert area of Sadat city, Menoufiya governorate, Egypt against three phytopathogenic fungi (Fusarium oxysporum, Fusarium solani and Rhizoctonia solani). Antifungal activity of plant extracts was performed using poison food technique. Aqueous extracts showed variability in inhibition of mycelial growth at 10%concentration. Among tested extracts Artemisia herb alba, Convolvulus arevensis, Conyza discordis, Deverra tortuosa, Fagonia arabica, Gymnocarpus decandrum, Limonium sinuatum, Mathiola livida, Pulicaria undulata, Rumex vesicarius, and Typha domnegensis were the most effective plants in reducing mycelial growth. Aqueous extract of Artemisia herb alba recorded the highest percent of inhibition in the radial growth of tested fungi that exceeded 45% in case of fusarium oxysporum.