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Strychnos ligustrina Blume is one of the potential plants for medicine that has been used by the local community in Indonesia for traditional medicine. Some studies showed that S. ligustrina parts had different activities, such as antimalarial, antibacterial, antimicrobial, antioxidant, and anticancer activities. Triterpenoids, phenolics, tannins, alkaloids, and flavonoids were detected in this species. Different plant parts and grow sites may affect the composition of chemical components. Therefore, the present study investigated the chemical components in different parts of S. ligustrina from some grow sites. The chemical components of different plant parts were analyzed by GC-MS and showed 51 compounds in total. The major constituents identified as mome inositol, heptadecene-(8)-carbonic acid-(1), palmitic acid, quinic acid, and stearic acid. The main active constituent of the antimalarial drug, strychnine, was also detected in this study. The PCA and cluster analysis of chemical components resulted in distinguished plant parts into three groups, whereas had shown no difference among the sites. In addition, the crucial compounds of this species that potential for antimalarial, strychnine, are only found in the leaf and stem. It has been shown that the leaf and stem are potential plant parts for the antimalarial agent.

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The antioxidant and α-glucosidase inhibitory activities of the methanolic leaf extracts of some subtropical plants were evaluated in the present study. Antioxidant activity was evaluated based on 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, reducing power, hydrogen peroxide and β-carotene bleaching assays. α-Glucosidase inhibitory activity and enzyme kinetics as well as the total phenolic content of the extracts were also investigated. Elaeocarpus sylvestris extract had the highest activities on all the antioxidant assays performed such as DPPH scavenging activity (IC50 12.7 ± 0.5 μg mL(-1)), reducing power (491.1 ± 6.3 mg QE g(-1) dry extract), hydrogen peroxide (IC50 65.6 ± 0.4 μg mL(-1)) and β-carotene bleaching assays (IC50 5.1 ± 1.9 μg mL(-1)). The total phenolic content of the E. sylvestris extract also had the highest values for gallic acid, quercetin and rutin equivalents (353.8 ± 28.6 mg GAE g(-1) dry extract; 294.9 ± 24.5 mg QE g(-1) dry extract; 663.0 ± 52.3 mg RE g(-1) dry extract, respectively). α-Glucosidase inhibition assay revealed that Distylium racemosum had the highest activity with an IC50 value of 22.6 ± 1.9 μg mL(-1). The results of the present study revealed the potencies of E. sylvestris, D. racemosum, Acer mono Maxim and Liquidambar styraciflua as alternative sources for antioxidants and α-glucosidase inhibitors.