Introduction:The Zika virus has the ability to tropism in neuronal cells of fetuses, congenitally causing neurological disorders. Objective: To discuss the relationship between congenital Zika virus infection and the onset of congenital neurological abnormalities in newborns, including their neurological manifestations, and their impact on quality of life. Methods: Bibliographic review developed from October to November 2022, with searches in the PubMed and LILACS databases, 15 articles being selected after applying inclusion criteria. Discussion: Infections in the first trimester of pregnancy are those that result in serious malformations, which reinforces the importance of adequate prenatal care. The diagnosis of infection during the gestational period consists of serological and ultrasonographic examinations. The main manifestation observed intrauterine and after birth was microcephaly, which is characterized by the interruption of brain growth, with little cortical differentiation. However, changes in sensory organs can also occur. Final considerations: The studies demonstrate advances in the screening of such changes through possible radiological and laboratory changes during prenatal care, and also through postnatal neuroimaging tests.