The University of Colorado Boulder (CU-Boulder) is known for strong programming in the sciences and a teaching faculty at the forefront of science education and reform. Librarians at CU-Boulder, in collaboration with science faculty, are challenged to improve undergraduate science education. Using rare, historic, and artistic works from Special Collections, the librarians employ active learning techniques that emphasize visual imagery to improve the quality of undergraduate learning in the sciences. This paper describes the fledgling program developed by CU-Boulder librarians to create a space for student-driven, collaborative learning using historic and visual scientific materials found in Special Collections.