Leukocyte-and platelet-rich fibrin (L-PRF) is a promising platelet concentrate in natural-guided healing, as it boosts wound healing and regeneration of soft and hard tissues. 1,2 In clinical practice, the morphology of L-PRF membranes is variable, which may be important as the fibrin network together with the entrapped cells determine wound healing. 3 The reason for this variation is not yet fully understood, and the potential impact of an antithrombotic therapyhas not yet been studied.