No abstract

Purpose: The impact of antiplatelet therapy with availability of CYP2C19 genotyping on bleeding in a real-world setting has not been extensively studied. Methods: Prospective, single-center, cohort study conducted between December 2015 and October 2019 with 1-year follow-up. Patients underwent percutaneous coronary intervention (PCI), CYP2C19 genotyping, and received P2Y12 inhibitor therapy. The primary outcome was time to first bleed of any severity using Bleeding Academic Research Consortium criteria. Secondary outcomes included time to first major bleed and rates of antiplatelet switching. Results: The primary outcome occurred in 697 of 2091 (33%) participants at a median of 15 days. Major bleeding occurred in 176 (8%) of patients. Compared to clopidogrel, treatment with ticagrelor or prasugrel was associated with increased risk of any bleeding (adjusted HR [aHR] 2.04, 95% CI 1.69-2.46). For patients without CYP2C19 no function alleles, treatment with prasugrel or ticagrelor was associated with increased risk of any bleeding (aHR 2.31, 95% CI 1.83-2.90). Similar associations were observed for major bleeding. No difference in ischemic events was observed. Among patients discharged on ticagrelor or prasugrel, 199 (36%) were de-escalated to clopidogrel within 1 year. De-escalation was more likely after a bleed if patients did not have a no function allele (35.9% vs 19.1%; P = .02). Conclusion: Bleeding is common in post-PCI patients on antiplatelet therapy. Patients on high potency agents had higher bleeding risk in the population at-large and in non-carriers of CYP2C19 no function alleles. Genotype-guided antiplatelet de-escalation should be further explored in prospective studies.

College students are at risk for making poor dietary choices that can cause significant health problems. A descriptive study was conducted to assess the effect of food consumption pattern on health status among nursing students at Dinsha Patel College of Nursing, Nadiad. A sample of 101students was selected by systematic random sampling technique. Five point Likert Scale was used to assess the food consumption pattern. The data was analyzed by using the descriptive and inferential statistics. The result of present study reveals 50(49%) students have more than 11 g/dl hemoglobin level, 56(55%) students are underweight, 73(72 %) students believes that they are taking balance diet. There is a statistically significant association with the perception regarding balanced diet and food consumption pattern and no significant association with other socio demographic variables such as age, sex, education, BMI, Hemoglobin level, religion, eating habits, residential status. The result shows 37(36.6%) students had unhealthy, 44(43.5%) students had average healthy, 19(18.8%) students had healthy diet pattern The study concluded that there is a need for health education programs that promote healthy food consumption pattern for nursing students.