Controller design of a nonlinear system is in general very difficult. One way to avoid such complexity is using a simplified model so that certain nonlinear control techniques can be easily applied. Using a linearized model could make the controller design even simpler. However, some control error is inevitable with a simplified model. Therefore, in this thesis, a neural network-based approach is proposed in order to compensate for the errors caused by using a simplified dynamic model.

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Background: β3-AR is an important factor involved in the activation of ERK protein signaling cascade, which can positively contribute to the regulation of adipose tissue metabolism and its conversion into brown adipose tissue. Diabetes mellitus can lead to dysfunction of these factors. Objectives: The current study aimed to investigate the effect of swimming training combined with cinnamon consumption on β3-AR and ERK2 gene expression in the visceral adipose tissue from diabetic rats. Methods: In this experimental-fundamental study, 35 male Wistar rats (mean weight: 200 ± 20 g) were selected and randomly assigned into four groups after the induction of diabetes by streptozotocin. These groups included: (1) healthy control, (2) control, (3) swimming, (4) cinnamon, and (5) swimming cinnamon (n = 7 in each group). The training groups were put through a five-days-a-week workout for four weeks according to the training protocol. Gene expression levels were measured by in vitro real-time PCR. The collected data were analyzed using one-way ANOVA and Tukey’s post hoc test. Results: The expression levels of β3-AR and ERK2 protein genes in the visceral adipose tissue of diabetic rats (P = 0.0001) were significantly affected by swimming training and cinnamon consumption. Conclusions: It was shown that cinnamon supplementation may have increased β3-AR levels, which was more effective than training, while training had a greater effect on ERK2 levels and increased them. Therefore, it was concluded that cinnamon consumption combined with training may have greatly contributed to the conversion of white adipose into brown adipose tissues.

Background: Today, the prevalence of obesity is seen as a major social challenge, affecting the general health of societies, which creates irreversible psychological, social, and economic consequences. In this regard, exercise training is one of the most important interventions in preventing and controlling obesity and the associated metabolic factors, which can be an appropriate and low-cost option for promoting community health and to some extent, managing metabolic diseases. Objectives: The present study was aimed at evaluating the impact of eight weeks of aerobic exercises on the levels of oxidized LDL cholesterol (Ox-LDL) and cardiovascular risk factors among obese and overweight females. Methods: This study was conducted in Gachsaran, Iran in 2018. Following a public call for inclusion as part of this quasiexperimental study, 22 obese women who met the inclusion criteria that was set for the study were chosen and were then divided into experimental (exercise training) (n = 11) and control (n = 11) groups. The subjects in the experimental group ran for eight weeks, three sessions per week for 45 minutes at an intensity of 55% to 65% of maximal oxygen consumption (Vo2max). Independent and paired sample t-test were used to account for the variations. For statistical analysis SPSS-21 software was used, and the significance level was set to be less than P < 0.05. Results: The findings indicated that the participants' body mass indices in the experimental group significantly decreased (P < 0.001). In addition, it was found that insulin resistance (HOMA-IR), insulin, glucose and lipoproteins (LDL-TC-TG), and C-reactive protein (CRP) were significantly diminished (P < 0.001), whereas the high-density lipoprotein (HDL) level went up (P < 0.001) following the treatment. No significant changes in Ox-LDL were found after eight weeks of aerobic exercise training (P = 0.07). Conclusions: It seems that eight weeks of exercise training with decreasing anthropometric indices, CRP levels, and insulin resistance, even without changing the levels of Ox-LDL, can prevent obesity and metabolic complications.