Background: Intravitreal injection is most popular universal intraocular procedure. it is important to consider the discomfort related with this procedure in order to ensure patient compliance and safety.Objective: To compare the pain in different quadrants correlated to intrvitreal bevacizumab injection. Material and Methods: Randomized controlled trial of four months was done In-patient Ophthalmology department, Pakistan Institute of Medical Sciences (PIMS) Islamabad between May-2020 to Sep-2020.In this study 120 patients were included (30 patients in each group) to measure the extent of pain while receiving an intravitreal bevacizumab injection. Sample size was calculated by WHO sample size calculator with 5% Level of significance, 80% Power of test.The data analyzed by using SPSS 23. Results: The results of pain score in our study showed that the mean pain score of the patients in Group A Superonasal Quadrant was 1.50 ± 0.51, in Group B Superotemporal Quadrant was 4.00 ± 0.91, in Group C Inferonasal Quadrant was 2.70 ± 0.84 and in Group D Inferotemporal Quadrant was 2.87 ± 0.78. The results of p value showed significant difference in pain score in groups. The Pain score is less in Group A Superonasal Quadrant as 1.50 ± 0.51 and more in Group B Superotemporal Quadrant as 4.00 ± 0.91. Conclusion: Superonasal Quadrant (SN Quadrant) was the less pain site as compared to others site i.e. Superotemporal Quadrant (ST quadrant), Inferonasal Quadrant (IN Quadrant) and Inferotemporal Quadrant (IT Quadrant). The most pain full site was Superotemporal Quadrant (ST quadrant).

Euryblepharon is a rare congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is less in size in the vertical dimension as compared with the horizontal dimension. It may be isolated or associated with other ocular anomalies (e.g. strabismus or telecanthus) or systemic anomalies (blepharo-cheilo-odontic syndrome)There can be associated lateral canthal misalignment and as a consequence lateral ectropion. The condition was first described by Desmarres in 1854. The average length of lid fissures is different in different ages as portrayed by Duke-Elder and Cook (1963) and Waardenburg and others (1961) ranging from 18.35mm at birth to 29.68 at 24 years of age. 50% of this increase occurs during first few (3-4) years of life.