The ability to accurately measure the flow rate, concentration, and temperature in real-time in micro total analysis systems (μTAS) is crucial when improving their practical sensing capabilities within extremely small volumes. Our label-free infrared (1500-1600 nm) opto-fluidic method, presented in this study, utilizes a cantilever-based flow meter integrated with two parallel optical fiber Fabry-Perot interferometers (FPIs). The first FPI serves as an ultra-sensitive flow meter and includes a Fiber Bragg Grating (FBG) tip for localized temperature sensing. The second FPI has a fabricated photopolymer micro-tip for highly sensitive refractive index (RI) determination. In this work, we performed 3-D simulation analysis to characterize cantilever deflection as well as temperature distribution and its effect on the RI. The experimental results from temperature cross-sensitivity analysis lead to real-time measurement resolutions of 5 nL min, 1 × 10 RIU and 0.05 °C, for the flow rate, refractive index, and temperature, respectively.

The dramatic advances of nanotechnology experienced in recent years enabled us to fabricate optical nanostructures or nano-antennas that greatly enhance the conversion of localised electromagnetic energy into radiation and vice versa. Nano-antennas offer the required improvements in terms of bandwidth, interaction strength and resolution for combining ultrafast spectroscopy, nano-optics and quantum optics to fundamentally push forward the possibility of the coherent optical access on individual nanostructures or even molecules above cryogenic temperatures, where dephasing processes typically occur at very short time scales. In this context, we discuss recent progress in the theoretical description of light-matter interaction at the nanoscale and related experimental findings. Moreover, we present concrete examples in support of our vision and propose a series of experiments that aim at exploring novel promising regimes of optical coherence and quantum optics in advanced spectroscopy. We envisage extensions to ultrafast and nonlinear phenomena, especially in the direction of multidimensional nanoscopy

The demonstration of biosensors based on the surface plasmon effect holds promise for future high-sensitive electrodeless biodetection. The combination of magnetic effects with surface plasmon waves brings additional freedom to improve sensitivity and signal selectivity. Stacking biosensors with two-dimensional (2-D) materials, e.g., graphene (Gr) and MoS2, can influence plasmon waves and facilitate surface physiochemical properties as additional versatility aspects. We demonstrate magnetoplasmonic biosensors through the detuning of surface plasmon oscillation modes affected by magnetic effect via the presence of the NiFe (Py) layer and different light absorbers of Gr, MoS2, and Au ultrathin layers in three stacks of Au/Py/M(MoS2, Gr, Au) trilayers. We found minimum reflection, resonance angle shift, and transverse magneto-optical Kerr effect (TMOKE) responses of all sensors in the presence of the ss-DNA monolayer. Very few changes of ∼5×10-7 in the ss-DNA's refractive index result in valuable TMOKE response. We found that the presence of three-layer Gr and two-layer MoS2 on top of the Au/Py bilayer can dramatically increase the sensitivity by nine and four times, respectively, than the conventional Au/Co/Au trilayer. Our results show the highest reported DNA sensitivity based on the coupling of light with 2-D materials in magnetoplasmonic devices.

The separation and manipulation of microparticles in lab on a chip devices have importance in point of care diagnostic tools and analytical applications. The separation and sorting of particles from biological and clinical samples can be performed using active and passive techniques. In passive techniques, no external force is applied while in active techniques by applying external force (e.g. electrical), higher separation efficiency is obtained. In this article, passive (pinched flow fractionation) and active (insulator-based dielectrophoresis) methods were combined to increase the separation efficiency at lower voltages. First by simulation, appropriate values of geometry and applied voltages for better focusing, separation, and lower Joule heating were obtained. Separation of 1.5 and 6 μm polystyrene microparticles was experimentally obtained at optimized geometry and low total applied voltage (25 V). Also, the trajectory of 1.5 μm microparticles was controlled by adjusting the total applied voltage.

We demonstrate a multilayer magnetoplasmonic structure fabricated from MoS2 monolayer to significantly increase the transverse magneto-optical Kerr effect (TMOKE) with a signal Q-factor more than 600.