The chemical reactivity of 6,8‐dibromo‐7‐hydroxychromone‐3‐carboxaldehyde (1) was studied towards some nitrogen nucleophilic reagents such as heterocyclic amines, 1,2‐N,N‐binucleophiles, 1,2‐N,O‐binucleophiles, 1,3‐N,N‐binucleophiles, 1,4‐N,N‐binucleophiles, 1,4‐N,O‐binucleophiles, and 1,4‐N,S‐binucleophiles under different reaction conditions.

No abstract

Background: Nursing is highly demanding and stressful profession. Job stress was found to be a stronger predictor of oxidative stress activity causing elevation of blood oxidative biomarkers. This work aimed to improve mental and psychological health of nurses through identification of prevalence of work stress among nurses at Zagazig university hospitals (ZUHs) and assess the association between work stress and blood oxidative biomarkers. Methods: A comparative cross-sectional study was conducted among 40 nurses and 40 administrative workers at ZUHs. Both two groups were subjected to a structured questionnaire about sociodemographic data and occupational history and two standardized questionnaires about job stress followed by laboratory investigations to measure blood oxidative biomarkers (Malonaldehyde MDA & Superoxide dismutase SOD). Results: This study showed that job stress and its level were significantly higher among nurses compared to their controls. this study indicated that prevalence of job stress in nurses at ZUHs was 85.0% compared to 22.5% in administrative controls where 65.0% and 20.0% of them had severe and moderate stress compared to 7.5% and 15.0% among controls.Furthermore, this study showed significantly high level of both blood oxidative biomarkers as both levels of MDA, [ Median (3.18) mol/ml] and SOD, [X±SD: 4.27± 0.40 U/ml] were significantly higher among nurses compared to their controls Conclusion: Job stress is realistic and widespread phenomena among nurses in ZUHs that have devastating consequences on nurse's health thus, effective preventive strategies should be designed and implemented.

No abstract

Background and Objectives: Risk-adapted therapy for children with HL is directed toward high survival, minimal toxicity and optimal quality of life, with long term follow up. We assess the impact of prognostic factors associated with local treatment failure of pediatric HL patients with unfavorable criteria treated with combined modality: Alternating ABVD (Doxorubicin, Bleomycin, Vinblastine and Decarbazine) and COEP (Cyclophosphamide, Oncovin, Etoposide and Prednisone) chemotherapy and response-based, involved-field radiation for newly diagnosed unfavorable pediatric HL patients, also will detect toxicities and long-term complications observed in the patients. Methods: This prospective study was carried out from January 2010 to January 2018, with a median follow up of 74 months (range 8 -103 months). 54 patients were eligible for this study stratified into two groups: intermediate risk (IR) and high-risk group (HR). Patients were treated with (4 -6 cycles) and (6 -8 cycles) respectively of alternating ABVD/COEP chemotherapy followed by involved-field radiation therapy (IFRT): 15 Gy for patients achieved complete response, and 25.5 Gy for those achieved a partial response. Results: 27 patients were IR and 27 patients were HR. There were 16 treatment failures; 5 patients had progressive disease; and 11 patients had a relapse. 9 patients died from their disease progression. The 5-year overall survival (OS) and event-free survival (EFS) rates (±SE) were 81.8% ± 5.7% and 71.8% ± 6.2% respectively. Multivariate analysis revealed that the only independent factor for inferior OS was radiotherapy. Conclusion: Treatment results of unfavourable HL patients in our study are satisfactory for with IR group but not for HR group who needs intensification of therapy. Radiotherapy is considered as a cornerstone in the treatment of the patients with unfavourable