Introduction: Lymphoma as a heterogeneous disease has various characteristics not only in the clinical manifestation but also in sociodemographic aspect. Epidemiological data with sociodemographic description in lymphoma is still unexplored. Objective: This study aimed to provide updated and detailed description of lymphoma with emphasis on patient characteristics, sociodemographic data and hematologic findings. Materials and Methods: This was an observational descriptive study with a cross-sectional design. The data were from the medical records in Dr. Sardjito Hospital, a national referral hospital in the Special Region of Yogyakarta Province Indonesia from 2012 to 2018. All lymphoma patients > 18 years were included. Patients’ characteristics, socio-demographic indicators, tumor characteristic and hematological finding were recorded. The difference of socio-demographic, clinical and laboratory characteristics between Non Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL) was analyzed with Chi-Square, Fisher-Exact, and Mann-Whitney test (P <0.05 was statistically significant). Results: There were 675 cases. Male predominated, mean age at diagnosis was 54.1 for NHL and 42.3 for HL. There was significant difference in the mean of age (p=0.000), occupation (P=0.035) and educational level (P=0.020) between NHL and HL patients. B cell NHL was found to be the most common type of lymphoma, with DLBCL being the most common histopathological type. Hematological findings were found to be within the normal range. Conclusion: There are significant difference in the mean of age, occupation and education level between NHL and HL patients. Further study to explain the scientific reasons of the difference are required.

Background: The burden of lymphoma is intensified with the presence of anemia. The type of anemia in lymphoma is predominantly anemia of chronic disease. Severe anemia is also often associated with advanced stages leading to poor prognosis and survival as well as a worse quality of life. Objective: In this study, we aimed to observe the incidence of anemia in lymphoma and to identify any associated clinical and laboratory factors. Methods: Data from lymphoma patients admitted between 2012 to 2018 with complete hemoglobin (Hb) levels were collected from the medical records in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Clinical and laboratory parameters included were age, sex, nutritional status, Ann Arbor staging, extranodal involvement, number of extranodal sites, Lactate Dehydrogenase (LDH) level, Eastern Cooperative Oncology Group (ECOG) performance status, platelet count, absolute lymphocyte count (ALC), white blood cell count (WBC), and lymphoma prognostic score (Non-Hodgkin Lymphoma/NHL using Index Prognostic International (IPI), Hodgkin’s Lymphoma/HL using International Prognostic Score (IPS)). Statistical analysis was done to observe the difference in any parameters between patients with anemia and non-anemia. Logistic regression was employed to model the relationship between associated or predictive factors and anemia incidence. Results: Six hundred eleven (611) lymphoma patients were involved in this study, 296 (48.5%) had anemia and 314 (51.5%) did not. Anemia was more prevalent in HL (17/ 33 cases or 51.5%) than in NHL (272/ 564 cases or 48.1%). Patients with anemia frequently presented with mild anemia in 142 (48%), followed by moderate anemia in 139 (46.9%). The incidence of anemia were significantly associated with male sex, advanced Ann Arbor stage (III-IV), underweight, elevated LDH level, abnormal platelet, absolute lymphocyte counts less than 600/mm3, elevated WBC count more than 15,000/mm3, and high total prognostic score (>3). Multivariate analysis demonstrated low or elevated platelet (P=0.044; 95% CI=1.03-8.09) as an independent predictor, meanwhile lymphocytopenia as protective factor (OR=0.05; 95% CI=0.00-0.54; P=0.013). Conclusion: Anemia commonly occurs in Indonesian lymphoma patients. There is an association and increased risk to develop anemia in male, Ann Arbor stage III-IV, underweight, elevated LDH, abnormal platelet, leukocytosis, and high total prognostic score. Abnormal platelet was an independent predictive factor, and lymphocytopenia is one of the protective factor.