Check for updateselbow. Overuse of the wrist in gripping and extension is the accepted etiology for LE [1]. This condition is not only a causes of pain, but it also plays a key role to loss of function at the elbow joint. As the result, reduction of normal activity and absence from work is possible. Conservative treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs), ice, rest, and reducing motion are required for settling the pain and inflammation [2]. A systematic review conducted by Bateman, et al. showed that surgical interventions in LE patients are not more effective than nonsurgical treatments [3].Local corticosteroid injection is a safe way to manage pain in LE. Smidt, et al. found a significant short-term reduction in pain and grip strength after corticosteroid injection compared to placebo, local anesthetics, or conservative treatments [4], however, long-term changes were not significant. In addition, corticosteroid injection was significantly better than placebo and naproxen in a clinical trial [5]. On the other hand, a study compared corticosteroid and ozone injection in a clinical trial and found better outcomes following ozone injection [6]. The safety of ozone therapy in LE is not established yet in the literature, however, there is no strong evidence of harm in this treatment method [7]. In this communication, we aimed to compare the severity of pain, tenderness, and involved elbow before and after the ozone injection treatment regimen in LE.