Background: The role of Ivermectin in improving the outcome of coronavirus disease of 2019 (COVID-19) symptoms was reported in several studies, while its effect on the pro-inflammatory cytokines triggering the cytokine storm is still not investigated. Method: This study aimed to investigate the role of Ivermectin on the proinflammatory cytokines in Covid-19 patients and correlated the results with the expression of miR-2909, miR-223-3p. Three hundred and twenty hospitalized patients with confirmed moderate-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were selected. The patients were divided into 2 groups: Group I treated with the Egyptian protocol of COVID-19 including (Ivermectin plus hydroxychloroquine). Group II was treated with the Egyptian protocol, including hydroxychloroquine and no Ivermectin. IL-6, IL-1b, procalcitonin, and gene expression of miR-2909, miR-223-3p, and Toll-like receptor 4 were done by real-time Polymerase Chain Reaction (PCR). Results : Patients treated with COVID-19 protocol including Ivermectin showed a significant decrease of cytokines levels (IL-6, IL-1, and procalcitonin), when compared with the other group, the cytokines levels improvement were positively correlated with miR-2029 expression and negatively correlated with the expression of miR-223-3p. Moderate ill COVID-19 patients treated with Ivermectin showed a significant decline in mortality rate and duration of hospital stay. Conclusion: Ivermectin is an effective drug in improving the outcome of SARS-CoV-2 patients with a significant decrease in mortality rate through decreasing cytokines expression via controlling miR-2029, miR-233-3p expressions.

Aim: to evaluate the role of magnetic resonance imaging in the assessment of sport injuries of the knee joint as an integral part of the musculoskeletal system. Methods: This study was done as a combined study between the Radiology Department of Zagazig University and the Radiology Department of University of California San Diego. It was conducted on 50 patients who were referred to the Radiology Department of the University of California San Diego. The patients were examined after sustaining different sports injuries of the knee joint. All the 50 patients were subjected to full history taking and Magnetic Resonance Imaging on the knee joint. The Magnetic Resonance Imaging results of 33 of these patients were compared with the results of knee arthroscopy. Results: The study included 50 patients complaining of sports related knee pain. The age of the patients ranged from 15 to 55 years with a mean age of 29.68 years. Most of the patients were males (38 patients), while 12 patients were females. The leading sports for knee injuries in this study were soccer, American football and running. The most common knee lesions were anterior cruciate ligament lesions (19 patients) and meniscal lesions (18 patients). In comparison with knee arthroscopy, magnetic resonance imaging revealed an overall 93.9 % sensitivity and 66.6 % specificity. Conclusion: Although arthroscopy has been considered the gold standard in knee sports injuries evaluation, MRI remains a reliable non-invasive modality that can reduce the use of diagnostic arthroscopy for evaluation of ligamentous, meniscal, bony and cartilaginous lesions.

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