Objectives: The aims of this study were to gain some insight with regard to the safety of the coelocentesis procedure and, to determine pH, pCO₂, and base excess status of the extracoelomic fluid 40 days after fertilization. Methods: Twenty-eight timed-mated baboons from the breeding colony of the Biological Resource Laboratory at the University of Illinois at Chicago were studied. The initial 19 animals were used to determine the ultrasonographic relations between the different compartments of the gestational sac from 38 to 62 days of pregnancy. Under aseptic conditions, in 9 animals coelocenteses were then performed, under continuous transvaginal ultrasound guidance to avoid the amniotic or yolk sacs. Extracoelomic fluid (1–5 ml) was aspirated using 10-ml syringes. Only one attempt of sampling was performed in each of the 9 animals. Extracoelomic fluid pH, pCO₂, and base excess were compared with maternal femoral venous blood. Pregnancies were followed by transabdominal ultrasound evaluations on day 3 after the procedure and weekly until day 140 after fertilization. Results: Extracoelomic fluid could be aspirated easily using a 20-gauge needle. Only one pregnancy loss was detected within 3 days after the procedure. No complications occurred in the remaining 8 pregnancies. Extracoelomic fluid pH (7.45 ± 0.01) and pCO₂ (39.9 ± 2.4 mm Hg) were significantly different from maternal femoral venous blood pH (7.41 ± 0.01) and pCO₂ (47.1 ± 1.4 mm Hg; p < 0.02), while base excess values were similar. Conclusions: This preliminary study performed at 40 days after fertilization in the baboon model suggests that the coelocentesis procedure is technically simple and presents a relatively low risk to mother and fetus if a 20-gauge needle is used and the amount of aspirated extracoelomic fluid is <3 cm³. At this gestational age, the extracoelomic fluid is more alkalotic than maternal femoral venous blood.

No abstract

An outbreak of novel coronavirus pneumonia occurred worldwide since December 2019, which had been named COVID-19 subsequently. It is extremely transmissive that infection in pregnant women were unavoidable. The delivery process will produce large amount of contaminated media, leaving a challenge for medical personnel to ensure both the safety of the mother and infant and good self-protection. Here, we report a 27 year woman had reverse transcription polymerase chain reaction-confirmed COVID-19 at 37 weeks 2 days of gestation. An emergency caesarean section at 38 weeks 2 days of gestation under spinal anaesthesia was performed for oligohydramnios with scar tenderness with strict protection for all personnel.

To determine the role of fetal adrenal gland measurements as a marker for onset of labour.

Introduction: Anemia in pregnancy is a public health problem of developing countries and has a significant impact on the health of mother and fetus. It is one of the leading cause responsible for maternal and perinatal morbidity and mortality. Aims: To find out the severity of anemia in pregnancy and its maternal and perinatal outcome. Methods: A prospective randomized case control study undertaken in the Department of Obstetrics and Gynecology, Nepalgunj Medical College, Kolhapur from September 2019 to August 2020. Total of 200 study subjects were enrolled, cases and control were 100 each, with cut off for anemia as 11gm/dl. Results: Out of 100 cases of anemia, 58 were mildly anemic (Hemoglobin: 10-10.9), 23 moderately (7-10) and 21 severely anemic (<7gm/dl). Anemic cases were found to have higher incidence of preterm birth (8%), postpartum hemorrhage (5%), and maternal morbidity (19%) than in non-anemic controls. Adverse fetal outcome in the form of preterm birth (8%), Intrauterine Growth Restriction (14%), Still birth (3%), Early neonatal death (4%), Low birth weight babies (22%), neonatal morbidity (17.5%) was more in anemic  group than non-anemic controls. Conclusion: Anemia in pregnancy has adverse effects on the mother and fetus. It is important to diagnose and treat anemia in pregnancy to ensure optimal health of mother and newborn.