The purpose of this research to know the quality of the question quantitatively (reliability, validity, distinguishing features, level of difficulty, and quality detractors). This research was a descriptive research. The population was all the answer sheets of students Mid Semester Exam II IPA class VIII SMP Pembangunan Laboratorium UNP and SMP Pertiwi Padang Siteba in academic year 2015/2016. Sample technique using total sampling with sample was 225 students answer sheets. Data were analyzed using the program ANATES ver.4.0.2. Based on the results of the research, then obtained: 1) the reliability of 0.55 with sufficient criteria; 2) the validity of 15% valid and 85% invalid; 3) distinguishing features about 15% good, 53% moderate and 13% bad; 4) the level of difficulty about 8% is very difficult, 25% difficult, 62% medium and 5% easy; 5) quality detractors about 88% of working and 12% do not function properly. Thus, it can be concluded that the matter has not met the criteria of a good question, so the need for revision.

Mitragynine is one of the dominant alkaloids presents in the Mitragyna speciosa which possesses several pharmacological properties such as antinociceptive, anti-inflammatory, and anti-cancer. Studies have reported various methods in extracting mitragynine, both conventional and renewable technology combined with acid-base techniques for the enrichment and purification of mitragynine from the extract of M. speciosa. Several chromatography and spectroscopy instruments such as HPLC, LC-MS, GC-MS, and NMR have been used to identify mitragynine and its content in both the extract and fraction mixtures. In this review, we aim to provide insight on how the methods of extraction, purification, and identification of mitragynine have been developed over the last few decades. This report also shows comparison among the various approaches in extracting mitragynine and points out the facts that different methods gave different yields of the compound.

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