No abstract

Context: Burden of diabetes mellitus is increasing gradually along with its complications. Nowadays along with fasting and postprandial plasma glucose (FPG and PPPG), HbA1c is included in the diagnosis and assessing prognosis. The current practice is samples for HbA1c and FPG, PPPG are collected in different vials (EDTA and Fluoride vial respectively).

Lipid prole though is a well established parameter to predict cardio vascular risk in patients suffering from type 2 diabetes mellitus(T2DM), at present lipid ratios are replacing these age old parameters. Among the lipid ratios Atherogenic index of plasma(AIP) and cholesterol/HDL(Chol/HDL) are found to be of great signicance. This cross-sectional study aimed to compare the predictive value of two lipid ratios, "Atherogenic index of plasma" (AIP) and "Cholesterol/HDL ratio" on basis of insulin resistance (IR) among 55 newly diagnosed cases with Type 2 Diabetes Mellitus (T2DM) and 50 control subjects. HOMA –IR (p value <0.0001), AIP (<0.001) and Cholesterol/HDL ratio (<0.001) were signicantly raised among case group in comparison to controls. Both AIP(r- 0.305, p-0.002) and Chol/HDL ratio(r- 0.23, p value- 0.018) was signicantly correlated with HOMA-IR. ROC curve of AIP and Chol/HDL ratio was plotted for identifying IR. There is no signicant difference between areas under curve (AUC) of AIP (AUC-0.656) and Chol/HDL ratio(AUC-0.630) (p value- 0.49). AIP was found to be correlated better with Insulin resistance than CHOL/HDL ratio. AUC in AIP was found to be slightly higher and overall sensitivity and specicity of AIP was found to be 66% and 69%, of Chol/HDL ratio was 46% and 76% to identify moderate to high-risk group: whereas it is 69%&47% of AIP and 87% and 32% of Chol/HDL ratio to identify low risk group. Both lipid ratios have some signicance in predicting cardio vascular risk in T2DM

Introduction: The rising prevalence of overweight and obesity in India has resulted in an increased prevalence of obesity-related comorbidities. Obesity predisposes affected people to subclinical inammation. Adipose tissue is an active endocrine organ that increases the released of inammatory mediators in obesity. Serum ferritin is well known acute phase reactant and also marker of acute and chronic inammation. In this study we tried to evaluate whether obesity correlate with change in serum ferritin level or not in Indian population. Materials and Methods: This cross sectional observational study was conducted in department of biochemistry of NRS Medical College and Hospital from January 2021 to October 2021. 105 otherwise healthy participants were selected for this study, among them 60 are female and 45 are male. The participants were assessed for BMI and serum ferritin. Result: Correlation test was performed between BMI and serum ferritin of both group (male and female). Statistically signicant positive correlation was found between serum ferritin and BMI among the female participants (P Value-0.018, r-0.304). Correlation is signicant at the 0.05 level (2-tailed). Conclusion: In this study BMI was positively correlated with serum ferritin among female participants. Adipose tissue may play a vital role in the production of acute phase reactants like ferritin.