Osteoarthritis is the most common cause of pain due to arthritis in women. Its high prevalence especially in the postmenopausal women, and the high rate of disability associated with the disease makes it a diagnostic and therapeutic priority. A hospital based cross sectional study was conducted in Burdwan Medical College, West Bengal, India on 76 postmenopausal women aged 45-70 years suffering from Osteoarthritis (OA) of the knee joint, which was diagnosed from symptoms, clinical examinations and radiographic findings. 150 subjects undergoing knee joint arthroscopy for chronic knee pain, meniscal tears or anterior cruciate ligament reconstruction were taken as control .Synovial fluid malondialdehyde (MDA) was measured as an index of synovial fluid lipid peroxidation. The width of knee joint space was measured from the radiographic plates to assess the disease severity. Knee joint radiographs were evaluated with the Kellgren-Lawrence grading scale .Furthermore both were correlated with oxidative stress parameters ,synovial fluid MDA levels to find out possible association between the oxidative stress induced damage and the disease progression. Results showed that there was a significant increase in MDA levels in patients with knee joint osteoarthritis as compared to the controls. Synovial MDA showed positive correlation with Kellgren-Lawrence grading and negative correlation with knee joint space width. The joint space width decreased and synovial MDA increase with increasing Kellgren-Lawrence grad.

Background: Hyper homocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Aims and Objective: The aim of this study is to investigate homocysteine in psoriatic patients and its relationship with the severity of the disease.Materials and Methods: A case control study in 50 patients with chronic plaque psoriasis and 50 healthy controls was performed. Total plasma homocysteine level, and PASI index were assessed in every patient.Results: Patients with psoriasis had plasma homocysteine levels higher than controls. The severity of psoriasis assessed according to PASI directly correlate either with plasma homocysteine.Conclusion: A significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. Our data directly correlate the high level of homocysteine with higher PASI scores.Asian Journal of Medical Sciences Vol.8(5) 2017 4-7

Introduction : Rheumatic fever (RF) is an autoimmune, multiorgan inflammatory disease. The patients develop carditis (50-78%), arthritis (35-88%), chorea (2-19%), erythema marginatum (< 6%) and subcutaneous nodules (< 1-13%). Ischemia modified albumin or cobalt binding albumin is one of new biomarker for inflammation and oxidative stress. Various previous studies indicate that acute rheumatic fever is associated with oxidative stress and inflammation. In the present study, we examined IMA, CRP, ESR and albumin levels in acute rheumatic fever.Material and method: This case control study was conductedbetween April 2017 to March 2018 in pediatrics department of Malda Medical College and Hospital. Study group composed of 42 children aged 5-18 years suffering from acute rheumatic fever diagnosed by modified jones criteria and they compared with 50 healthy age and sex match control. The IMA levels were compared among groups, and the association to acute phase reactants were investigated.Results: Values ofserumischemia modified albumin, ESR and C Reactive Protein were significantly higher in cases compared to control group (p value ≤0.001). But no significant differencewas found between values of serum albumin in cases compared to control group. Positive correlation was found between cases serum IMA and ESR, C-Reactive protein.Conclusion: Serumischemia modified albumin were significantly higher in children with acute rheumatic fever compared to control group, so IMA could be used as a biomarker in diagnosis of ARF. However, further multicenter and larger case studies are needed to provide stronger evidence.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 222-225

Background: The commonest cause of mortality & morbidity in Type 2 diabetes is cerebrovascular accident & coronary artery disease. The study shows that only good blood glucose control, along with BP control in Type 2 diabetic patients cannot reduce mortality & morbidity due to cerebrovascular accident & coronary artery disease; but dyslipidaemia & life style modification is the cornerstone to reduce mortality & morbidity for those events. Dyslipidaemia in diabetes mellitus is a common accompaniment. Prevalence of lipid profile abnormality may not uncommon in young Type 2 diabetics which is common in elderly Type 2 diabetic patients.Aims: The aim of the study is to look after the prevalence of dyslipidaemia in younger age group & to compare it with elderly age group with the same anthropometric parameters.Methodolgy: A prospective cohort study was undertaken to find out the prevalence of diabetic dyslipidemia in younger and adult age group among patients attending Medical OPD & Diabetic clinic in M.G.M. Medical college &L.S.K. Hospital, Kishanganj, Bihar& to compare it between young and adult age group.Results: In the present study majority of patients of older age group have high LDL and low HDL in comparison to younger age group. Increased triglyceride level is not significantly high.Conclusion: Aggressive therapy of diabetic dyslipidemia will probably reduce the risk of CHD in patients with diabetes. Primary therapy should be directed first at lowering LDL levels & improving HDL levels.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.557-563

Problem statement : perinatal asphyxia, neonatal or birth asphyxia is a medical condition from deprivation of oxygen to a newborn infant long enough during the process to cause physical usually to the brain. And it is almost all neonatal deaths occur in our rural and urban area. Where the majority is delivered at homes with negligible antenatal care and poor prenatal services. Methods: In this collaborative study conducted prospective, descriptive study. As a case of 150 newborn babies and as a control 1190 newborn babies are fulfilled the selection criteria for prenatal and birth asphyxia . Results: Incidence of birth asphyxia in relation to ante partum and intrapartum factors. And shows that mother with complication like eclampsia, APH, PROM, cord accidents, failed progress of labor, obstructive labor & prolong 2 nd stage of labor, etc were more likely to deliver asphyxiated baby, and analysis of maternal risk factors for birth asphyxia. Many pathological, biochemical & metabolic changes occurs as a result of birth asphyxia. And the data were analyzed by slandered statistical test, namely, Z test, Chi square test, and uniovariate and ultivariate logistic regression analysis of risk factor. Conclusion: In our study it was observed that, Pregnancy related complication in rural & urban population of Kishanganj district was mostly Eclampsia, pre-eclamptic toxaemia, Oligohydramnios, PROM(M24hr) etc. To prevent birth asphyxia trained personal and neonatal resuscitation equipment should be mandatory in all maternity home/hospital because prevention is the best and be only option to reduce the Pre natal & birth asphyxia.