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Purpose. To evaluate the visual performance and clinical outcomes after implantation of Lucidis EDOF IOL following cataract surgery. Design. In this retrospective study, medical records from all enrolled patients were analyzed, and the following information was extracted retrospectively over 3 months following surgery. Materials and Methods. We reviewed retrospectively 181 eyes of 98 patients, who underwent cataract surgery with Lucidis extended depth of focus IOL. Results. 44 patients were males (45%) and 54 were females (55%). The average age of the study population was 68 ± 11 years. The mean preoperative BCVA (logMAR) was 0.19 ± 0.18. The mean root mean square (RMS) high order aberration (HOA) was 0.18 ± 0.1. Monocular BCVA results were 0.02 ± 0.04 (logMAR) and 0.028 ± 0.04 (logMAR) 1 month and 3 months postoperatively, respectively. Between the baseline and 1-month measures, monocular distance BCVA improved by an average of 0.17 ± 0.14 logMAR ( p  = 0.0001). Between the baseline and 3-month postoperative measures, monocular distance BCVA improved by an average of 0.16 ± 0.13 logMAR ( p  = 0.0001). Monocular UDVA 1 and 3 months postoperatively was 0.08 ± 0.1 logMAR and 0.067 ± 0.08 logMAR, respectively. 1-Month postoperative binocular UDVA was 0.036 ± 0.05 logMAR, binocular UIVA was 0.1 ± 0.08 logMAR, and binocular UNVA was 0.12 ± 0.14 logMAR. 3-Month postoperative binocular UDVA was 0.038 ± 0.05 logMAR, binocular UIVA was 0.09 ± 0.1 logMAR, and binocular UNVA was 0.16 ± 0.14 logMAR. Conclusions. Lucidis EDOF IOL achieves good visual performances in all distances.

surface receptor signaling pathway, and regulation of immune system processes. In addition, both complement C3 and adenosine deaminase (ADA) genes were upregulated in tumor gastric tissues. IFI30 gene encoded by Gamma-interferon-inducible lysosomal thiol reductase (GILT) whose function is closely associated with bacterial activities was also upregulated in the tumor tissue. WES data revealed that two recurrent missense mutations (K169R and N175S) of CDC27 were found in~20% of MALT lymphoma patients. Upregulated expression of complement C3 gene in tumor tissues suggests that the defense mechanisms of innate immunity have been activated due to the bacterial infection. Upregulated ADA agrees on the findings from previous studies showing higher ADA activities in Hp-infected patients. Upregulation of IFI30 in tumor tissues supports evidence of enhanced bacterial hemolysis and bacterial replication/infection activities. On top of that, repeatedly observed mutations in a cell cycle-associated gene, CDC27, may have a role to play in cell growth inhibition.Lymphoid Tissue (MALT). ABSTRACT lymphomas. We found poor outcome in cases with DUSP22 expression. How can we define this controversy? It is known that DUSP22 regulates MAPK signal transduction but the effect of DUSP22 on MAPKs is controversial. Since there have been several conflicting reports regarding its substrate specificity. One report showed that DUSP22 dephosphorylates ERK2 in vitro, while other studies showed that DUSP22 enhances JNK activation but not p38 and ERK2. Therefore, further studies are required to clarify the physiological role of DUSP22. We found poor overall survival in cases with DUSP22 expression and we need further studies about the prognostic significance of DUSP22 expression in indolent lymphomas.Background: Duodenal-type follicular lymphoma (DTFL) is a rare variant of FL characterized by duodenal involvement and favorable prognosis. A clinicogenetic risk model m7-FLIPI was originally proposed for the prognostication of nodal FL. There are few studies analyzing the m7-FLIPI score and gene mutations according to the sites of involvement in patients with DTFL. Methods: This study included 11 patients with DTFL diagnosed according to the 2017 WHO classification between 2005 and 2016 at Mie University Hospital. Five patients with involvement of mesenteric lymph nodes were excluded in total 16 patients. Intestinal involvement was examined by double-balloon endoscopy and/or capsule endoscopes in addition to esophagogastroduodenoscopy and colonoscopy in all the patients. Genomic DNA was examined using the AmpliSeq Comprehensive Cancer Panel investigating the exonic regions of 409 genes and direct sequencing of MEF2 (exon 2 to 3).Results: The median age was 59 years (42-84) and 6 patients were women. Sites of lymphomatous involvement were as follows: second part of the duodenum, 100% of the patients; third part of the duodenum, 82%; first part of the duodenum, 0%; jejunum, 72%; ileum, 36%; colon, 9%; stomach, 0%. Lymphoma cells by all the patients wer...

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