Anuran amphibians metamorphosis represents a model for the study of different processes, including tissue remodeling. One of the body�s systems whose morphological and structural properties are deeply transformed during metamorphosis is the digestive tract. The only structure in the digestive tract which is destroyed and then replaced with a new tissue (histolysis and histogenesis) under the action of oxidative stress and hormones, is the intestinal epithelium. Oxidative stress may be related to the production of malondialdehyde and the accumulation of lipofuscin. The two substances can be considered biomarkers of this process.