Malondialdehyde and Lipofuscin Biomarkers of Oxidative Stress in Rana temporaria temporaria During Metamorphosis

Abstract

Anuran amphibians metamorphosis represents a model for the study of different processes, including tissue remodeling. One of the body�s systems whose morphological and structural properties are deeply transformed during metamorphosis is the digestive tract. The only structure in the digestive tract which is destroyed and then replaced with a new tissue (histolysis and histogenesis) under the action of oxidative stress and hormones, is the intestinal epithelium. Oxidative stress may be related to the production of malondialdehyde and the accumulation of lipofuscin. The two substances can be considered biomarkers of this process.

Correlations Between Oxidative Stress and Apoptosis During Anuran Metamorphosis

“…Enterocytes are endowed with an enzymatic charge specific of the larval feedind. They are destroyed and replaced with the juvenile epithelium resulting from the action of the existing cells in the underlying cellular nests [33].…”

“…At the level of enterocytes, we observed the changes in the nucleus in relation with the antioxidant enzyme activities. The reactive oxygen species produce oxidative changes in the cell DNA [33]. In the early stages of metamorphosis climax, a condensation of nuclear material is produced and the nuclei appear pyknotics in photon microscopy ( fig.…”

The Study of Antioxidant Capacity in Extracts from Vegetal Sources with Hypoglycaemic Action

“…These vegetative organs contain many active compounds that no longer will be present in the mature plant. In addition, because they contain vitamins, oligoelements and minerals, they are richer in nucleic acids and growth hormones than other vegetal tissues [7][8][9][10][11][12][13][14][15][16][17][18].…”

Evaluation of Phenolic Compounds Content and Antioxidant Capacity of Some Medicinal Plants, Potentially Used for Their Preventive Role Against Various Oral Diseases

“…Recent studies on antioxidants have demonstrated their important role in offset this imbalance [10,11]. Many antioxidant compounds possess antiinflammator y, antiatherosclerotic [12], antiproliferative, antitumor [13], antimutagenic, anticarcinogenic, antibacterial or antiviral activities [13][14][15][16][17][18]. An important group of antioxidants are phenolic compounds [10,12].…”