Background and Purpose Aberrant gyral folding is a key feature in the diagnosis of many cerebral malformations. However, in fetal life it is particularly challenging to confidently diagnose aberrant folding due to the rapid spatiotemporal changes of gyral development. Currently, there is no resource to measure how an individual fetal brain compares to normal spatiotemporal variations. In this study we assess the potential for automatic analysis of early sulcal patterns to detect individual fetal brains with cerebral abnormalities. Materials and Methods Triplane MR images were aligned to create a motion-corrected volume for each individual fetal brain and cortical plate surfaces were extracted. Sulcal basins were automatically identified on the cortical plate surface and compared with a combined set generated from 9 normal fetal brain templates. Sulcal pattern similarities to the templates were quantified using multivariate geometric features and inter-sulcal relationships for 14 normal fetal brains and 5 fetal brains proven abnormal on postnatal MRI. Results were compared to gyrifixation index. Results Significantly reduced sulcal pattern similarities to normal templates were found in all abnormal individual fetuses compared to normal fetuses (mean similarity [normal, abnormal], left: 0.818, 0.752; P < .001, right: 0.810, 0.753; P < .01). Altered location and depth patterns of sulcal basins were the primary distinguishing features. Gyrification index was not significantly different between the normal and abnormal groups. Conclusion Automated analysis of interrelated patterning of early primary sulci could outperform traditional gyrification index and has the potential to quantitatively detect individual fetuses with emerging abnormal sulcal patterns.

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An electron microscope study and quantitation of myelinated and unmyelinated fibers of seven nerve biopsies performed in sporadic cases of idiopathic sensory neuropathy is reported. The number of myelinated fibers is markedly decreased or absent in every case. On the contrary, the unmyelinated fiber numbers are normal or increased. In most cases, the small diameter myelinated and unmyelinated fibers proportions are higher than those of control biopsies. The electron microscope study discloses evidence of degeneration of Wallerian tye and regeneration is also indicated by quantitative studies. Regenerative phenomena seen more obvious in sporadic cases than in previously reported studies of familial cases.

Objective. The aim of the study was to analyse the results of the PET-SAÚDE/GRADUASUS in dental formation and integration between university, service and community. Method. This study reports the experience of one of the tutorial teams of the PET-SAÚDE/GRADUASUS program. Between June 2016 and April 2017 diagnosis, strategic planning and an intervention were carried out in the community of São Raimundo I Family Health Strategy (ESF) in Governador Valadares-MG.  Educational actions were carried out at the operative groups, home visits, schools and the waiting rooms of the Basic Unit, focusing on priorities of public oral health problems. Results. As results of the educational actions, the over demand of the public health professional decreased. The community benefited by the increase assistance regarding health promotion and prevention actions, motivating an active participation of the population in its own  health-disease process. In the student perception, the knowledge about the health and the public health system was improve, through  the application of theoretical concepts in the reality of health practices, and the acquisition of  capacities and abilities necessaries  for the practice in health. Conclusion. The actions performed as part of the program, promoted positive impacts in the professional formation, benefited the service and the community  and the  integration between them.  ;