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The combination of structural parameters derived from CSLO and SLP in a multivariate discriminant formula may enhance the ability to diagnose glaucoma. Further studies investigating a random population are needed in order to test the validity of this formula.

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ABSTRACT.Purpose: To test the correlation between optic disc topography (as measured by confocal scanning laser ophthalmoscopy [CSLO]) and retinal nerve fibre layer (RNFL) measurements (as measured by scanning laser polarimetry [SLP]) in glaucoma. Material and Methods: A total of 112 patients with primary open-angle glaucoma and 88 normal individuals were enrolled in the study. All individuals underwent a thorough ophthalmic evaluation, a 24-2 full threshold Humphrey visual field, SLP with the GDx (Version 1.0.12) and CSLO with the TOPSS. Receiver operator characteristic curves were created for each individual CSLO and SLP parameter. Linear correlations between the four best parameters from each device were calculated. Finally, linear correlations between the same variables, controlled for the severity of visual field damage, were calculated. Results: The best individual parameters in the diagnosis of glaucoma for each device were cup area, vertical cup : disc ratio, cup : disc area ratio and average cup depth for CSLO, and the Number, maximum modulation, ellipse modulation and superior nasal for SLP. Moderate to strong correlations were observed in 62% of the pairs. However, only 6% and 12% of the correlations remained moderate when we controlled for the visual field mean deviation and correct pattern standard deviation, respectively. Conclusions: The correlation between optic disc topography and RNFL measurements in glaucoma patients is moderate and highly dependent on the level of visual field loss.

ABSTRACT.Purpose: To report a patient with morning glory syndrome in combination with posterior pituitary ectopia and to emphasize the need for early recognition of this syndrome as an important step towards the diagnosis and treatment of the systemic anomalies that may be associated with it. Methods: We present a 7-year-old boy who showed short stature, nystagmus, inward deviation and low vision. Ophthalmological and general physical examinations, further endocrine evaluation and magnetic resonance imaging (MRI) of the brain and sella turcica were performed. Results: Both fundi showed symptoms of morning glory syndrome. The discs were pink and deeply excavated, and were surrounded by a ring of chorioretinal pigmentary disturbance. Magnetic resonance imaging revealed the absence of the infundibulum and posterior pituitary ectopia. Growth hormone studies confirmed the diagnosis of growth hormone deficiency. Therapy with recombinant human growth hormone was initiated. Conclusions: Although most cases of morning glory syndrome occur as isolated ocular abnormalities, it may occur in association with systemic anomalies, including posterior pituitary ectopia and hypopituitarism. A complete general physical examination and growth evaluation is important for early detection and treatment, resulting in benefit for these patients.