Background: Angiosarcomas are highly aggressive and malignant blood vessel tumors. Rarely, angiosarcomas develop in the breast following conservative therapy, namely radiotherapy. Case Report: A 70-year-old female patient presented with dark purple discoloration of the skin of the right breast. 6 years earlier, the patient had undergone conservative surgery for invasive ductal carcinoma of the right breast. According to the breast-conserving surgery protocol, the patient had been treated with radiotherapy to the residual breast tissue. The patient's annual mammograms and ultrasound findings were normal. The skin lesion was superficially localized mostly at the border between the upper and lower medial quadrants of the breast (between 2 and 4 o'clock) and above the areola. The borders were uneven; the dimensions were 7 cm × 4 cm. The mammogram was classified as Breast Imaging Report and Data System (BI-RADS) 2. Ultrasound examination showed a well-vascularized structure, although the etiology was unclear. A tissue biopsy revealed angiosarcoma. The patient underwent radical simplex mastectomy. Following surgery, the patient underwent chemotherapy. Tests excluded metastases for a follow-up period of 5 years. Conclusion: Angiosarcomas that develop after radiotherapy following breast-conserving surgery are sporadic, but it is important to take this possible incident into consideration during treatment.

Aim: Renal cell carcinoma is one of the deadliest cancers which takes the third place among malignant carcinomas of the genitourinary tract. This case report describes the rare case of a large fast-growing metastasis of renal cell cancer in an unusual location with the short time of its appearance, but with an unexpected clinical course after its treatment. Case report: A 60-year-old female patient presented with a fist-sized formation on the scalp. During physical examination, the mass was determined to be firm, infiltrative, fixed, and painless on palpation. The formation had appeared a month prior to arrival, characterized by fast growth. The patient underwent a radical nephrectomy six months earlier due to RCC. A cranial radiogram showed osteolysis of the neurocranium, while an MRI of the brain confirmed the mass belonged to the scalp, no brain infiltration, measuring 82 × 60 × 74 mm. Fine needle aspiration isolated malignant cells of an adenocarcinoma, origin undetermined. The patient underwent surgery to remove the mass along with the effected neurocranium, and the resulting bone defect was reconstructed using Palacos. Postoperative recovery went well, and the pathohistological analysis confirmed renal cancer metastasis. PET-CT didn't show suspicious lesions for distal metastasis for a period of 2 years. Conclusion: Renal cell carcinoma commonly metastasizes to the lung. This case report presents the rare case of a large fast-growing renal cancer metastasis to an unusual location, with a short time for metastasis appearance. In spite of that we have shown two years follow up of remission.

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