The dialysis procedure for kidney patients is of vital importance and consists of diverting blood from the body to a machine that will do the work of the kidneys, filtering the blood and eliminating toxins. The properly filtered blood returns to the patient's body, a process called hemodialysis. In the hemodialysis filtration process, water is used to dilute a solution, which will have contact with the blood through a semi-permeable membrane, through the diffusion process. The water used in hemodialysis must undergo rigorous treatment to eliminate unwanted substances. Consolidation Ordinance 5/2017 and RDC No. 11/2014 establishes the maximum limits allowed for physicochemical and microbiological contaminants in drinking water and water for hemodialysis, as well as operational procedures to prevent contamination. The control of the proper functioning of water treatment systems for hemodialysis and the quality of this water is carried out through a daily checklist, as well as monthly and semi-annual procedures. Thus, a list of parameters with priorities of responsibility for the occurrence of certain problems is needed so that the solution of these impasses occurs in a timely manner, favoring the care of hemodialysis patients with maximum brevity and safety. In this work, the Multivariate Statistics methodology known as Principal Component Analysis (PCA) was used to identify and classify relevant parameters in order of priority. For the PCA application, experimental data related to 30 days of operation of a treatment system associated with a hospital unit were used. Eleven factors were selected and from these historical data eight were selected after adequate preparation of the information matrix. In order of priority regarding the electrical conductivity of the water in the treatment system, eight relevant parameters were chosen. In solving problems with the treatment system, ACP indicated priority to address, chronologically, the variables: pre-coal filter pressure, post-coal filter pressure, feed pump pressure, post-coal conductivity, Pre-filter hardness softener , pre sand filter pH, pre-coal free residual chlorine and feed water temperature