The aim of this study was to translate and cross-culturally adapt the condition-specific instrument Impact of Fixed Appliances Measure (IFAM), assessing its validity and reliability for use among Brazilian children/adolescents. The IFAM was translated, back-translated, cross-culturally adapted, and pilot-tested. The Brazilian version of the IFAM (B-IFAM) was tested on 161 10-to-18-year-old children/adolescents. Internal consistency was assessed using Cronbach's alpha (α) and test-retest reliability by intraclass correlation coefficients (ICC). Construct validity was conducted using Pearson correlation among the overall and subscales of the B-IFAM. Discriminant validity was evaluated by comparisons of B-IFAM's means and SD with children's/adolescents' sex (Student t-test). Internal consistency was 0.89 for overall score and 0.55-0.86 for subscales. ICC for test-retest reliability was 0.81 for overall score and 0.55-0.78 for subscales. The overall score of the B-IFAM presented large correlation coefficients with most subscales (r = 0.52-0.74), supporting construct validity. Discriminant validity demonstrated statistically significant difference in the overall score, aesthetics, and physical impact subscales among female and male children's/adolescents' (p < 0.05). In the conclusion, the B-IFAM overall score and some subscales demonstrated adequate psychometric properties regarding reliability and validity. The study achieved a specific-condition instrument feasible for use on Brazilian children/adolescents who wear fixed orthodontic appliances.

Background Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery. Methods We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered. Results Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals. Conclusion The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment. Trial registration Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

Introdução: A Qualidade de Vida Relacionada à Saúde Bucal (QVRSB) descreve como as diferentes condições relacionadas à saúde bucal afetam a execução de atividades diárias de um indivíduo, tais como falar, mastigar e dormir, além do seu bem-estar e sua vida social. Objetivo: O presente estudo teve como objetivo investigar o impacto da má oclusão na QVRSB de crianças e adolescentes que estavam em tratamento ortodôntico com aparelho fixo, e os fatores associados. Materiais e métodos: foi selecionada uma amostra de 161 indivíduos entre 10 e 18 anos, de ambos os sexos, em tratamento na clínica de Especialização em Ortodontia da Universidade Federal de Minas Gerais. As crianças/adolescentes responderam à versão brasileira do Child-Oral Impacts on Daily Performances (Child-OIDP), que é subdividido em 8 domínios que avaliam os impactos que as condições bucais podem ter sobre a execução de atividades diárias; os pais/responsáveis responderam a um formulário socioeconômico; e o pesquisador coletou informações da ficha clínica e dos modelos ortodônticos dos participantes, como tipo de aparelho, má oclusão (Dental Aesthetic Index - DAI), extração de pré-molares por indicação ortodôntica e tempo de tratamento. Foram realizadas análises bivariadas e multivariadas através do programa Statistical Package for the Social Sciences for Windows (SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp.). Resultados: As variáveis que apresentaram um valor de p<0,20 foram má oclusão/DAI (p=0,032) e escolaridade dos pais (p=0,184) e foram incorporados na regressão logística (p<0,05). No modelo multivariado final, observou-se que indivíduos com má oclusão ausente/leve (DAI ≤25) possuíam 2,05 (95%IC=1,05–4,00) menos chances de apresentar impacto na QVRSB quando comparadas com aqueles com má oclusão mais grave (DAI≥26). Conclusões: a gravidade da má oclusão foi um importante fator de impacto na QVRSB de indivíduos jovens sob tratamento ortodôntico. Descritores: Qualidade de Vida. Má oclusão. Ortodontia. Odontopediatria.