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A novel photochemical technological route for one-step functionalization of a graphene surface with an azide-modified DNA aptamer for biomarkers is developed. The methodology is demonstrated for the functionalization of a DNA aptamer for an N-terminal B-type natriuretic peptide (NT-proBNP) heart failure biomarker on the surface of a graphene channel within a system based on a liquid-gated graphene field effect transistor (GFET). The limit of detection (LOD) of the aptamer-functionalized sensor is 0.01 pg/mL with short response time (75 s) for clinically relevant concentrations of the cardiac biomarker, which could be of relevance for point-of-care (POC) applications. The novel methodology could be applicable for the development of different graphene-based biosensors for fast, stable, real-time, and highly sensitive detection of disease markers.

We analyze the presence of a microwave neutral-line-associated source (NLS) in a super-active region NOAA 12673, which produced a number of geo-effective events in September 2017. To estimate the NLS position, we use data from the Siberian Radioheliograph in a range 4–8 GHz and from the Nobeyama Radioheliograph at 17 GHz. Calculation of the coronal magnetic field in a non-linear force-free approximation has revealed an extended structure consisting of interconnected magnetic flux ropes, located practically along the entire length of the main polarity separation line of the photospheric magnetic field. NLS is projected into the region of the strongest horizontal magnetic field, where the main energy of this structure is concentrated. During each X-class flare, the active region lost magnetic helicity and became a CME source.

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