The unprecedented development of the information and communication technologies sector has accelerated the spectacular changes in societies and employment trends worldwide. The adoption of ICTs in innovation systems has been a key factor in the overall competitiveness of economic regions and national economies. This paper studies the impact of ICT on regional development. To do so, a modelling approach is used to develop a framework-guidance tool that can formulate what-if scenarios of smart technology enhancement in a regional innovation system. The model is applied in two Greek regions with different development backgrounds, and the findings emphasise the importance of smart technologies in regional development in both cases.

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