Objective: In  diabetes  mellitus (DM) type 2, there  is  a  very  high  risk  of developing cardiovascular  (CV) events.  We aimed to study the total CV risk of the indigenous people of  Kyrgyzstan with  impaired carbohydrate metabolism (DM type 2 and impaired glucose tolerance, IGT), depending on  the region of residence (low and high altitudes), and to  develop targeted preventive measures. Methods: Overall, 248 families (992 people) in the Naryn (high-altitude) (study group) and 260 families (1041 people) in the Chui region (low-altitude) (control group) were surveyed and  363 people with DM type 2 and IGT were identified, of which: 138 people in the study group and 225 people in the control group. Results: In patients with DM type 2 and IGT, moderate CV risk was found in the low-altitude and high-altitude in men and women aged 46–65 years, the  leading risk factor in men is BMI&qt;25 kg/m2; in women, hypertension (HT)  and hypercholesterolemia. A high risk of  CV  complications was detected only in the low-altitude in men aged 46–65 years, the leading risk factor is HT. High and very high risk of CV complications  are rarely found both in the low-altitude and in the high-altitude. Conclusion: During stratification of total CV risk, 363 people with carbohydrate metabolism disorders (DM type 2 and IGT) of  2033 native population living in 2  regions  of Kyrgyzstan revealed features of the total CV risk: BMI&qt;25kg/m2 for men of  high- altitude  and  low-altitude,  HT  and hypercholesterolemia  for  women of high-altitude, and for men, low-altitude only HT. Both in the high-altitude and in the low-altitude, low and moderate CV risk are predominantly expressed, and high and very high CV risk are rare.

The resistance of polyester sewing thread to spontaneous microflora formed on the surface of the thread during production, storage, and developing in conditions of high humidity was investigated. The change in the breaking strength, abrasion resistance, whiteness, and the overall color difference of the thread induced by microflora is approximated by exponential equations. The kinetics of the change in the electrostatic field surface charge density of the polyester thread is approximated by a linear regression equation. The kinetic curves and their approximation examined in the article can be used to predict the properties of poly(ethylene terephthalate) thread stored or used in conditions of high humidity and exposure to spontaneous microflora.Microorganisms are an integral part of the world that surrounds us, interacting not only with living organisms but also with materials of different application and origin, including synthetic materials. The published information on the change in the properties of synthetic fibre materials caused by microorganisms is very limited. Although there is no doubt about the possibility of damage of synthetic fibres by microbial populations, the characteristics of the change in their properties have still been inadequately investigated.There are many studies of the interaction of chemical fibres and microorganisms [1][2][3][4]. The change in the physicomechanical properties of high-strength fibres caused by edaphon is being investigated in the Department of Materials Science at the St. Petersburg State University of Technology and Design [5][6][7]. The characteristics of the change in the properties of dyed polyester sewing thread (PES ST) caused by microorganisms are examined in the present article.The thread is used in fabricating any garment, including garments used in conditions that favor growth of different groups of microorganisms. Like other textile materials, sewing thread is usually dyed, and the dyes can have both a stimulating and an antimicrobial effect on microorganisms.We investigated reinforced polyester sewing thread 35 LL dyed with disperse dyes in manufacturing conditions with traditional technology and unbleached thread. The basic characteristics of the threads are reported in Table 1, and the structural formulas of the dyes used in dyeing are shown in Fig. 1.In real conditions of use, textile materials are exposed to many microorganisms, including both microscopic fungi and bacteria. For this reason, the sewing thread was exposed to the spontaneous microflora formed on them during production and storage, and growing in conditions of high humidity. The thread, in the form of skeins 50 m long, was placed in sterile desiccators and held at 90-100% relative humidity at a temperature of 28±2°C for up to 180 days. Samples were collected every 30 days to measure the property indexes. The thread was air-dried and conditioned in standard conditions according to GOST 10681-75.The strength of the ST was determined by breaking a single thread with plotting of the stress-st...

Objective: Highlands Aksay of Naryn region of Kyrgyzstan has specific natural and climatic conditions and located at altitude of 3000 m above sea level. We aimed to study 10-years risk of type 2 diabetes (T2DM) in the native population of highlands Aksay of Naryn Region of Kyrgyzstan. Methods: Overall, 152 indigenous people (50 men and 102 women) of highlands Aksay of Naryn region (3260-3680 m) were studied using one-step sampling. The study was random, subjected to the conditions of singleness and territoriality. FINDRISС questionnaire was used to calculate the risk of T2DM. Results: Women of highlands Aksay had a significantly higher prevalence of waist circumference (WC) &qt;80 cm, body mass index (BMI) &qt;25 kg/m2 and irregular intake of fruits and vegetables, whereas men showed irregular intake of fruits and vegetables, BMI&qt;25 kg/m2, and WC&qt; 94 cm. Conclusion: The features of the 10-year-old risk of developing T2DM in the indigenous people of the highlands of Kyrgyzstan include the predominance of abdominal obesity and the irregular intake of fruits and vegetables. When stratifying the risks of developing T2DM, low risk predominates, and a very high risk does not occur. The prognosis of the indigenous people of the highlands of Kyrgyzstan regarding the risk of developing T2DM depends on phenotypic factors and living conditions in the highlands, with hypoxia playing the leading role. Among the mountain people of Kyrgyzstan, metabolic factors are dominated by abdominal obesity and, probably, to reduce the risks of developing diabetes, along with the fight against other negative factors, regular intake of vegetables and fruits is effective.