In the Kyrgyz population, a 10-year high risk of T2DM development is greater among residents of LAlts as compared with HAlts, irrespective of gender. No very high-risk group was detected in residents of low or HAlts. The leading composites of FINDRISC score are increased WC and BMI, possibly due to irregular intake of vegetables and fruits that are dependent on the altitude of residence and age.

Aim. The aim of this literature review is to generalize existing approaches to the pathogenetic treatment of gastritis as a basis for the prevention of gastric cancer, as well as to submit a resolution of a scientific symposium that brought together gastroenterologists from a number of CIS countries.Background.  H. pylori infection is widespread in CIS countries. The proportion of infected adults in the population ranges from 60 % to over 90 %. This causes a high incidence of chronic gastritis and other diseases associated with H. pylori. In 2012, gastric cancer was recognized as the 3rd leading malignant disease in the Kyrgyz Republic and the Republic of Uzbekistan, 5th — in Belarus and Kazakhstan, 6th — in Armenia and the Russian Federation. According to the standardized cancer mortality rate, gastric cancer takes the 1st place in Kyrgyzstan and Uzbekistan, 2nd — in Belarus, 3rd — in Kazakhstan, and 4th — in Armenia and Russia. In every case of H. pylori detection, it is important to make a decision about the expediency of eradication therapy. This is particularly significant, since H. pylori eradication has been recognized as an effective method of gastric cancer prevention. In addition, H. pylori eradication therapy in patients suffering from chronic gastritis with dyspepsia symptoms serves as the firstchoice therapy that allows patients with dyspepsia resulting from H. pylori infection to be excluded. The choice of the H. pylori eradication therapy scheme is determined by the protocols (standards) of patient management accepted in the respective CIS country. A high efficacy of H. pylori infection eradication is shown to be provided by bismuthcontaining schemes.Conclusion.  Opportunistic screening of H. pylori is carried out by general practitioners, district physicians, gastroenterologists and other specialists. The most effective method of gastric cancer prevention is the eradication therapy of H. pylori infection in chronic gastritis. The maximal positive potential of such a therapy is realized when it is performed before the atrophic changes of the gastric mucosa have appeared.

Objective: In  diabetes  mellitus (DM) type 2, there  is  a  very  high  risk  of developing cardiovascular  (CV) events.  We aimed to study the total CV risk of the indigenous people of  Kyrgyzstan with  impaired carbohydrate metabolism (DM type 2 and impaired glucose tolerance, IGT), depending on  the region of residence (low and high altitudes), and to  develop targeted preventive measures. Methods: Overall, 248 families (992 people) in the Naryn (high-altitude) (study group) and 260 families (1041 people) in the Chui region (low-altitude) (control group) were surveyed and  363 people with DM type 2 and IGT were identified, of which: 138 people in the study group and 225 people in the control group. Results: In patients with DM type 2 and IGT, moderate CV risk was found in the low-altitude and high-altitude in men and women aged 46–65 years, the  leading risk factor in men is BMI&qt;25 kg/m2; in women, hypertension (HT)  and hypercholesterolemia. A high risk of  CV  complications was detected only in the low-altitude in men aged 46–65 years, the leading risk factor is HT. High and very high risk of CV complications  are rarely found both in the low-altitude and in the high-altitude. Conclusion: During stratification of total CV risk, 363 people with carbohydrate metabolism disorders (DM type 2 and IGT) of  2033 native population living in 2  regions  of Kyrgyzstan revealed features of the total CV risk: BMI&qt;25kg/m2 for men of  high- altitude  and  low-altitude,  HT  and hypercholesterolemia  for  women of high-altitude, and for men, low-altitude only HT. Both in the high-altitude and in the low-altitude, low and moderate CV risk are predominantly expressed, and high and very high CV risk are rare.

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