Antioksidan terkandung dalam berbagai jenis buah dan sayuran antara lain tomat (Lycopersicum esculentum Mill). Tomat memiliki kandungan likopen, flavonoid dan vitamin C sebagai antioksidan. Tomat dapat dibuat menjadi sari buah dengan menggunakan metode pengepresan. Sari buah tomat dapat dibuat sediaan farmasi dalam bentuk hand and body lotion (H&B lotion). Tujuan penelitian ini yaitu untuk mengetahui karakteristik fisik dan stabilitas mekanik H&B lotion sari buah tomat serta untuk mengetahui aktivitas antioksidannya. Variabel bebas dalam penelitian ini adalah konsentrasi sari buah tomat sebagai zat aktif sebesar 20%, 35%, dan 50%. Variabel terikat dari penelitian ini adalah adalah karakteristik fisik lotion sari buah tomatmeliputi organoleptis, pH, viskositas, tipe emulsi, stabilitas mekanik sediaan lotion dan aktivitas antioksidan lotion sari buah tomat. Data yang diperoleh dari hasil penelitian dibandingkan dengan literatur yang relevan dan dilakukan analisis statistik dengan taraf kepercayaan 95%. Hasil penelitian menyatakan konsentrasi sari buah tomat tidak berpengaruh pada karakteristik fisik sediaan H&B lotion. Hasil uji stabilitas mekanik sediaan pada semua formula mengalami pemisahan fase. H&B lotion sari buah tomat mempunyai aktivitas antioksidan dengan nilai IC50 pada formula I sebesar 5,697 µg/mL, formula II sebesar6,530 µg/mL, dan formula III sebesar 5,106 µg/mL.

AbstrakBerbagai masalah kesehatan, khususnya terkait obat masih ditemui di masyarakat. Berbagai permasalahan terkait obat dapat dikarenakan masyarakat kurang paham tentang penggunaan dan penanganan obat dengan benar. Salah satu cara pengelolaan obat yang baik dan benar adalah dengan menerapkan program DAGUSIBU (DApatkan, GUnakan, SImpan, BUang). Berdasarkan informasi yang diperoleh, guru dan karyawan SMA Theresiana I Semarang belum pernah mendapatkan informasi tentang DAGUSIBU sehingga perlu dilakukan sosialisasi tentang DAGUSIBU. Adanya kegiatan ini diharapkan para guru dan karyawan SMA Theresiana I Semarang dapat membagikan informasi tentang penggunaan dan penanganan obat yang benar kepada anggota keluarganya serta siswa siswi SMA Theresiana I Semarang. Metode yang digunakan dalam kegiatan ini adalah pengenalan masalah, pelaksanaan sosialisasi DAGUSIBU dengan cara penyuluhan, diskusi interaktif, dan pambagian buku saku DAGUSIBU. Kegiatan sosialisasi tentang DAGUSIBU berjalan dengan lancar. Tingkat kehadiran peserta sebanyak 89,3%. Para peserta yang hadir sangat antusias dalam mendengarkan penjelasan dan aktif bertanya terkait penggunaan obat dan penanganannya. Hal ini dapat menunjang terwujudnya program pemerintah dalam peningkatan pelayanan kesehatan bagi masyarakat. Sosialisasi ini meningkatkan pemahaman peserta tentang pengelolaan obat dengan benar, diharapkan peserta dapat menerapkan pengetahuan yang telah diperoleh dalam lingkungan keluarga dan masyarakat. Kata Kunci: DAGUSIBU; obat; sosialisasi. AbstractSome parts of our society are having problems with handling drugs properly. One of the causes is not all people understand how to heal their sickness with many kinds of drugs. Various drugs-society related problems can be caused by people's lack of understanding about the use and handling of drugs correctly. One way to inform society how to manage drugs properly is to implement the DAGUSIBU (DApatkan, GUnakan, SImpan, BUang). Based on the information obtained, the teachers and employees of SMA Theresiana I Semarang have never received information about DAGUSIBU. That’s why it is necessary to socialize DAGUSIBU in their community. The purpose of this activity is to make them understand and share information about the correct way to receive, apply, install and waste the medicines among their family members and students. The method used in this dissemination is ellucidation by socializing problems of handling drugs improperly as introduction and then the implementation of DAGUSIBU by means of counseling, interactive discussions, and the distribution of DAGUSIBU pocket books. The dissemination about DAGUSIBU went smoothly. The attendance rate was 89.3%. The participants were very enthusiastic in listening to the explanation and actively asked about drugs-society related problems. This can support the realization of government programs in improving health services for the community. This socialization increases participants' understanding of drug management correctly, it is expected that participants can apply the knowledge gained in the family and community environment. Keywords: DAGUSIBU; drug; socialization.

Tomatoes contain lycopene which is an antioxidant. Antioxidant preparations can be made in the form of a cream with components of an oil phase, a water phase and an emulsifier. Emulsifiers that can be used are triethanolamine (TEA) and stearic acid. This study aims to determine the effect of triethanolamine and stearic acid as emulsifiers on the physical quality and mechanical stability of tomatoes extract cream. The use of triethanolamine and stearic acid with a ratio of 2%:5%; 3%:10%; 4%:15%. The test are the physical characteristics of tomatoes extract cream included organoleptic, homogeneity, cream type, pH, viscosity, spreadability, adhesion, protection and mechanical stability using the centrifugation method. The results of the phytochemical screening of tomatoes extract were positive for triterpenoids. The test results of the three cream formulas are odorless, semi-solid form, light orange to white color, homogeneous, cream type M/A, pH 5.25 - 6.26; viscosity 5,376 cP - 14,370 cP, spreadability 4 - 5,067 cm, adhesion 4 - 11.6 seconds, protection power 2 - 5.2 seconds. The three cream formulas did not undergo phase separation. The higher concentration of TEA and stearic acid had an effect on viscosity, pH value, adhesion, dispersibility and protection, but had no effect on organoleptic, homogeneity, cream type, and stability. tomatoes extract cream with a concentration of TEA:stearic acid 2%:5% gave the best physical quality.

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Dengue hemorrhagic fever (DHF) threatens people in the rainy season. DHF is one of the major public health problems in Indonesia. These problems encourage an effort to eradicate  Ae. aegypti larvae by using natural larvicide. One of the plants that can be used as natural larvicides is avocado seeds (Persea americana Seed) which contain saponin. This study aims to determine the larvacidal activity of avocado seed extract sandgranules with LC50 of 8.87 mg.mL-1 against Ae. aegypti larvae. This study is an experimental research with a complete random design in a unidirectional pattern. The independent variable in this study is the variation concentration of Explotab as a disintegrant agent ie 2, 3, and 4%. Sand granules of avocado seed extract are made by wet granulation method. Results of the larvacidal activity test of  avocado seed extract sand granules were analyzed by calculating the percentage of larvae mortality and statistical analysis using SPSS. The results of this study is the larvacidal activity of pure avocado seed extract with LC50 8.87 mg. L-1 is greater than the avocado seed extract sand granules. The addition of Explotab did not affect the total larvae mortality, but there was a significant difference in larvae mortality at 5 hours of sand granules exposure with explotab concentration of 3% and 4% (a significance value <0.05).