Background Steroid use for COVID-19 is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by SARS-CoV-2. This study aimed at evaluating at evaluating the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. Methods Parallel, double-blind, placebo-controlled, randomized, phase IIb clinical trial was performed with hospitalized patients aged ≥ 18 years with clinical, epidemiological and/or radiological suspected COVID-19, at a tertiary care facility in Manaus, Brazil. Patients were randomly allocated (1:1 ratio) to receive either intravenous MP (0.5 mg/kg) or placebo (saline solution), twice daily, for 5 days. A modified intention-to-treat (mITT) analysis was conducted. The primary outcome was 28-day mortality. ClinicalTrials Identifier NCT04343729. Findings From April 18 to June 16, 2020, 647 patients were screened, 416 randomized, and 393 analyzed as mITT, MP in 194 and placebo in 199 individuals. SARS-CoV-2 infection was confirmed by RT-PCR in 81.3%. Mortality at day 28 was not different between groups. A subgroup analysis showed that patients over 60 years in the MP group had a lower mortality rate at day 28. Patients in the MP arm tended to need more insulin therapy, and no difference was seen in virus clearance in respiratory secretion until day 7. Conclusion The findings of this study suggest that a short course of MP in hospitalized patients with COVID-19 did not reduce mortality in the overall population.

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A nível mundial, a busca constante pelo corpo descrito como “ideal” - disseminado às grandes massas pelos meios de comunicação - tem tomado proporções inimagináveis.  Assim, a busca frenética por exercícios que forneçam bons resultados, em curto espaço de tempo, estão no topo da lista relacionada a busca do corpo ideal, principalmente no público feminino. Sob essa perspectiva muitos exercícios se ajustam a rotina do dia a dia e a falta de tempo, entre eles o HIIT (High Intensity Interval Training), que em português significa Treino Intervalado de Alta Intensidade. Com base no exposto, o objetivo deste artigo é propor uma revisão de literatura sobre a influência HIIT na composição corporal feminina. Com base nos diversos autores e estudos analisados, foi possível concluir que independente da condição física, ou da faixa etária, grau de obesidade ou de sedentarismo, com síndromes e doenças crônicas não-transmissíveis, ou com boa saúde e aptidão física, o HIIT se demonstra uma ótima ferramenta para a mudança significativa na composição corporal feminina, bem como mudanças estéticas e funcionais do corpo de maneira geral.