Diabetic Retinopathy (DR) is a microvascular complication of Diabetes Mellitus (DM) caused by hyperglycemia and oxidative stress that is prevalent to the blindness risk. Manganese superoxide dismutase (MnSOD) gene affect the oxidative damage and progression of DR severity. This study aims to determine the association of patient characteristics on the severity and prevalence of Single Nucleotide Polymorphism (SNP) V16A in the MnSOD gene in DR patients at Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali. Twelve (12) subjects with Non-Proliferative DR and 21 subjects with Proliferative DR were enrolled. Patient characteristics (age, T2DM duration, BMI, blood pressure) were associated to the DR severity using cross-sectional analytic study. While to detect the status of the SNP V16A MnSOD gene using descriptive experimental study. DNA segment amplification was performed using the PCR method, sequencing was performed to detect the base pattern at the location of the SNP. A domination of the VV genotype in the SNP V16A MnSOD gene was present in all subjects (100%). The majority of subjects were female (51,5%), age range 40-65 years (84,9%), T2DM duration <10 years (60,6%), normal BMI (60,6%). Blood pressure was dominated with non hypertension 60,6%, with a history of oral anti hypertensive. No significant association was found between patient characteristics and the DR severity (p<0,05). We may conclude that wildtype variant (VV) SNP V16A MnSOD gene was dominated in this finding. There is no significant association between patient characteristics and the severity of DR in Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali. Keywords: Diabetic Retinopathy, MnSOD gene, SNP V16A
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.