Synadenium umbellatum Pax, popularly known as "cola-nota", is a medicinal plant that grows in tropical regions. Latex of this plant is used to treat various diseases such as diabetes mellitus, Hansen´s disease, tripanosomiases, leukemia and several malignant tumors. In the present study, the angiogenic activity of S. umbellatum latex was evaluated using the chick embryo chorioallantoic membrane (CAM) assay. Results showed significant increase of the vascular net (p < 0.05) compared to the negative control (H 2 O). The histological analysis was in accordance with the results obtained. In conclusion, our data indicate that S. umbellatum latex, under the conditions of this research, presented angiogenic effect.Keywords: Angiogenesis, latex, chick chorioallantoic membrane, Synadenium umbellatum. Atividade angiogênica do látex de Synadenium umbellatum Pax ResumoSynadenium umbellatum Pax, popularmente conhecida como "cola-nota", é uma planta medicinal que cresce em regiões tropicais. O látex desta planta tem sido utilizado no tratamento de várias doenças, como diabetes mellitus, hanseníase, tripanossomíases, leucemia e vários tumores malignos. No presente estudo, a atividade angiogênica do látex de S. umbellatum foi avaliada pelo ensaio da membrana corio-alantóide (MCA) de ovo embrionado de galinha. Os resultados mostraram aumento significativo da rede vascular (p < 0.05) em relação ao controle negativo (H 2 O). A análise histológica está em concordância com os resultados obtidos. Em conclusão, os dados indicaram que, nas condições experimentais deste estudo, o látex de S. umbellatum exibiu efeito angiogênico.Palavras-chave: Angiogênese, látex, membrana corio-alantóide de galinha, Synadenium umbellatum.
Cochlospermum regium (Mart. and Schr.) Pilger, popularly known as "algodãozinho do campo", is a medicinal plant that grows in the Cerrado of Brazil. This plant has been used in traditional medicine against various diseases such as leucorrhoea, gastritis and ulcers. It has also been effective in treating skin problems like pimples, boils and blotches. In the present study, the in vivo antimutagenicity of aqueous extract of C. regium was evaluated. The Micronucleus Test was performed in polychromatic erythrocytes from Swiss male mice treated with one of the four doses of extract of the plant (19, 38, 76 and 114 mg.kg -1 body weight), administered by intraperitonial injection (i.p.) simultaneously with cyclophosphamide (24 mg.kg -1 b.w.) or mitomycin C (4 mg.kg -1 b.w.). The cytotoxicity was evaluated by polychromatic and normochromatic erythrocytes ratio (PCE/NCE). The results showed no significant reduction of the micronucleated polychromatic erythrocytes frequency (P > 0.05). In conclusion, the data indicate that C. regium roots aqueous extract, for the conditions used, did not exhibit the antimutagenic effect.Keywords: Cochlospermum regium, antimutagenicity, micronucleus, mice. Ausência de antimutagenicidade do Cochlospermum regium pelo Teste do Micronúcleo em camundongos ResumoCochlospermum regium (Mart. & Schr.) Pilger, conhecido popularmente como "algodãozinho-do-campo", é uma planta medicinal que cresce no Cerrado brasileiro. Esta planta tem sido utilizada na medicina tradicional contra várias doenças como leucorréia, gastrites e úlceras. Esta também tem se mostrado efetiva no tratamento de doenças de pele como espinhas, furúnculos e manchas. No presente estudo, foi avaliada a antimutagenicidade do extrato aquoso de C. regium pelo Teste do Micronúcleo in vivo. Este ensaio foi realizado em eritrócitos policromáticos de camundongos machos Swiss tratados com quatro concentrações diferentes do extrato da planta (19, 38, 76 e 114 mg.kg -1 por peso corpóreo), administrado por injeção intraperitonial (i.p.) simultaneamente com ciclofosfamida (24 mg.kg -1 p.c.) ou mitomicina C (4 mg.kg -1 p.c.). A citotoxicidade foi avaliada pela razão eritrócitos policromáticos e normocromáticos (PCE/NCE). Os resultados obtidos não mostraram redução significativa da freqüência de eritrócitos policromáticos micronucleados (P > 0,05). Em conclusão, os resultados indicam que o extrato aquoso de raiz de C. regium, para as condições utilizadas, não exibiu efeito antimutagênico.Palavras-chave: Cochlospermum regium, antimutagenicidade, micronúcleo, camundongos.
Human Tooth Banks (HTB) tries to overbear academic activities by providing human teeth, which are fundamental for preclinical, clinical and experimental applications. This study, which took place at the Federal University of Ceara-UFC, considered the cognition of students and professors of Dentistry on HTB. Aim: This study aimed at the investigation of the reality and importance of this tool for the undergraduate course, research as well as for the legal acquisition of this dental organ. Methods: This is a quantitative study, that a semi-structured questionnaire was used. The Statistical Package for the Social Sciences program analyzed all the data, considering the reliability of 95% and using Fisher's Exact test or the Person Chi-square test. Results: Although only 6.4% of the participants were familiarized with HTB, 99.1% considered their existence important. As for the use of human teeth, 93.5% reported having used HTB during the course, but only 41.1% requested authorization to handle. Conclusion: The knowledge of students and professors of Dentistry about HTB and its legality in obtaining this body is insufficient, although the use of human teeth and its high importance is attributed to the existence of HTB in dental schools.
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