Solid lipid nanoparticle-based vectors are promising gene delivery systems for corneal diseases, including inflammation.

In this study, we propose a mesh-free (particle-based) Smoothed Particle Hydrodynamics model for simulating a Rayleigh collapse. Both empty and gas cavities are investigates and the role of heat diffusion is also accounted for. The system behaves very differently according to the ratio between the characteristic time of collapse and the characteristic time of thermal diffusion. This study identifies five different possible behaviours that range from isothermal to adiabatic.

The non-symmetrical collapse of an empty cylindrical cavity is modeled using Smoothed Particle Hydrodynamics. The presence of a nearby surface produces an anisotropic pressure field generating a high-velocity jet that hits the surface. The collapse follows a different dynamic based on the initial distance between the center of the cavity and the surface. When the distance is greater than the cavity radius (detached cavity) the surface is hit by traveling shock waves. When the distance is less than the cavity radius (attached cavity) the surface is directly hit by the jet and later by other shock waves generated in the last stages of the of the collapse. The results show that the surface is hit by a stronger shock when distance between the center of the cavity and the surface is zero while showing more complex double peaks behavior for other distances.

Planar laser-induced fluorescence (PLIF) and electrical resistance tomography (ERT) were applied simultaneously to monitor the mixing performance of a KM static mixer for the blending of non-Newtonian fluids of dissimilar rheologies in the laminar regime. The areal distribution method was used to obtain quantitative information from the ERT tomograms and the PLIF images. Comparison of the ERT and PLIF results demonstrates the ability of ERT to detect the mixing performance in cases of poor mixing within the resolution of the measurement, though the accuracy decreases as the condition of perfect mixing is approached. Thus, ERT has the potential to detect poor mixing within the confines of its resolution limit and the required conductivity contrast, providing potential rapid at-line measurement for industrial practitioners.