There was significant variability in S epidermidis adhesion to IOLs as a function of design, material, surface modification, and FN preadsorption. Application of the findings may foster new developments to further reduce the major complication in cataract surgery, infective endophthalmitis.

ABSTRACT.Purpose: To evaluate the index of contrast sensitivity (ICS) in eyes after cataract surgery with various intraocular lens designs and to compare with the area under log contrast sensitivity curve (AULCSF). Methods: The study comprised 395 eyes of 198 patients in the age of 73.1 AE 7.86 years receiving 11 different aspheric IOL designs (aberration-free and correcting) and a spherical (IOL) as control group. Follow-up examination after bilateral cataract surgery was completed within 71 AE 21.4 days after second IOL implantation. Patients underwent complete examination and biometry before surgery. The follow-up examination included visual acuity, pupil diameter, residual spherical aberration and mesopic as well as photopic contrast sensitivity (CS) measured with the Optec 6500 Functional Vision Analyzer. From the contrast sensitivity, we calculated the ICS according to Haughom and Strand. Results: The median mesopic ICS was À144, À131 and À85, and the median photopic ICS was À289, À285 and À212 for the spherical, aberration-free and aberration-correcting IOL group, respectively. While we could not detect a significant difference between the aberration groups in some spatial frequencies, the ICS showed a significant difference between the aberration-correcting and the aberration-free or the spherical group, respectively. No significant difference was found between the aberration-free and the spherical group. Conclusions: The ICS is a useful index for evaluation of overall CS and comparison of different patient groups. With aberration-correcting IOLs, ICS was statistically better than with aberration-free or spherical IOLs, whereas the latter two showed no significant difference.

This study associates IOL materials, surface modifications, and the role of FN preadsorption with SCA values reflecting surface hydrophobicity versus hydrophilicity. It provides a rationale for specific IOL selection as a function of the clinical setting, and a basis for IOL development using tailored surface physicochemistry to enhance biocompatibility and to reduce susceptibility to implant infection.

Retinocortical processing of visual information is impaired in patients with peripheral vestibular disorders such as Meniere's disease. Therefore, these patients are probably not good candidates for MIOL implantation, which requires an intact sensory system with rigorous visuovestibular interaction.